Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study

    July 2024 in “ Clinical Cosmetic and Investigational Dermatology ”
    Hongtao Liu, Xiao Huang, Haibin Wei, Yingqi Nong
    Image of study
    TLDR Certain immune cells are linked to non-scarring hair loss, suggesting potential for immune-targeted treatments.
    This study used Mendelian Randomization to explore the relationship between non-scarring hair loss (NSHL) and immune cells in a European population of 272,100 individuals. It identified 31 immune cell phenotypes associated with NSHL, with 19 showing protective effects and 12 promoting NSHL. Key protective phenotypes included CD4+ CD8dim T cells and CD86+ plasmacytoid dendritic cells, while PDL-1 on CD14- CD16+ monocytes and CD25 on resting CD4 regulatory T cells were among the strongest promoters of NSHL. The findings suggest potential targets for immunotherapy in treating NSHL, although further research is needed, especially in more diverse populations.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Why is no one pointing out dandruff as the number 1 evidence/symptom of MPB?

      in Chat  55 upvotes 1 year ago
      The post discusses the theory that persistent dandruff in areas prone to hair loss could be a sign of hair follicles dying due to DHT, indicating balding. The responses vary, with some users noting improvements in dandruff and hair loss with treatments like Dutasteride, while others experienced hair loss without dandruff.

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Comprehensive Microneedling Guide

      in Microneedling  295 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

    Similar Research

    5 / 1000+ results