Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study

    July 2024 in “ Clinical Cosmetic and Investigational Dermatology ”
    Hongtao Liu, Xiao Huang, Haibin Wei, Yingqi Nong
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    TLDR Certain immune cells are linked to non-scarring hair loss, suggesting potential for immune-targeted treatments.
    This study used Mendelian Randomization to explore the relationship between non-scarring hair loss (NSHL) and immune cells in a European population of 272,100 individuals. It identified 31 immune cell phenotypes associated with NSHL, with 19 showing protective effects and 12 promoting NSHL. Key protective phenotypes included CD4+ CD8dim T cells and CD86+ plasmacytoid dendritic cells, while PDL-1 on CD14- CD16+ monocytes and CD25 on resting CD4 regulatory T cells were among the strongest promoters of NSHL. The findings suggest potential targets for immunotherapy in treating NSHL, although further research is needed, especially in more diverse populations.
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