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GlossaryMendelian randomization

uses genetic variations to infer causal relationships in biology

Mendelian randomization is a research method that uses genetic variations to study the causal effects of a modifiable exposure (like diet or lifestyle) on a disease. By leveraging the random assortment of genes from parents to offspring, it mimics the design of a randomized controlled trial, helping to determine whether an observed association between a risk factor and a health outcome is likely to be causal rather than due to confounding factors.

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research Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization

29 citations, October 2020 in “eLife”

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

research Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

4 citations, January 2023 in “Frontiers in Immunology”

Shorter telomeres in white blood cells may increase the risk of a common type of hair loss.

Causal Link of Distinct Mental Disorders with Androgenetic Alopecia and Alopecia Areata: A Bidirectional Two-Sample Mendelian Randomization Study

research Causal Link of Distinct Mental Disorders with Androgenetic Alopecia and Alopecia Areata: A Bidirectional Two-Sample Mendelian Randomization Study

July 2025 in “Clinical Cosmetic and Investigational Dermatology”

Major depression disorder increases the risk of alopecia areata, and vice versa.

Potential Therapeutic Targets for Androgenetic Alopecia in Obese Individuals Revealed by Gut Microbiome Analysis: A Mendelian Randomization Study

research Potential Therapeutic Targets for Androgenetic Alopecia in Obese Individuals Revealed by Gut Microbiome Analysis: A Mendelian Randomization Study

May 2025 in “Nutrients”

Gut bacteria pathways may help treat hair loss in obese people.

research Causal Relationship Between Gut Microbiota And Androgenic Alopecia: A Mendelian Randomization Analysis

May 2025 in “Annals of surgical case reports & images.”

Certain gut bacteria may protect against hair loss, while others may increase the risk.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 8 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.