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GlossaryMendelian randomization

uses genetic variations to infer causal relationships in biology

Mendelian randomization is a research method that uses genetic variations to study the causal effects of a modifiable exposure (like diet or lifestyle) on a disease. By leveraging the random assortment of genes from parents to offspring, it mimics the design of a randomized controlled trial, helping to determine whether an observed association between a risk factor and a health outcome is likely to be causal rather than due to confounding factors.

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research Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization

29 citations , October 2020 in “eLife”

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

research Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

4 citations , January 2023 in “Frontiers in Immunology”

Shorter telomeres in white blood cells may increase the risk of a common type of hair loss.

research The genetic link between thyroid dysfunction and alopecia areata: a bidirectional two-sample Mendelian randomization study

3 citations , August 2024 in “Frontiers in Endocrinology”

The study investigates the genetic link between thyroid dysfunction (TD) and alopecia areata (AA) using a bidirectional two-sample Mendelian randomization approach. It provides strong genetic evidence supporting a causal relationship between TD and AA, highlighting potential causes of AA in patients. This finding is significant for improving the management and treatment strategies for individuals with AA.

research Retracted: Genetic Association Between Asthma and Alopecia Areata: A Two-Sample Mendelian Randomization Study

3 citations , July 2024 in “Skin Research and Technology”

Asthma may increase the risk of alopecia areata.

research Association Between Genetically Predicted Rheumatoid Arthritis And Alopecia Areata: A Two-Sample Mendelian Randomization Study

2 citations , October 2023 in “Frontiers in Immunology”

People with rheumatoid arthritis have a higher risk of developing alopecia areata.

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community Hair Loss Causes Depression. Not Finasteride.

in Research/Science 179 upvotes 3 weeks ago

Finasteride and Dutasteride do not cause depression or mood disorders; hair loss itself may be a more significant factor. Some users experience side effects from Finasteride, but it is generally well-tolerated.

community Hair Loss Ruins Your Mind: 10x rate of BDD. PF S is not real

in Research/Science 39 upvotes 1 month ago

Hair loss is linked to a higher rate of body dysmorphic disorder (BDD), OCD, and depression. Finasteride and dutasteride are not linked to increased suicidal risk, though some users report mental health side effects.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.