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GlossaryMendelian randomization

uses genetic variations to infer causal relationships in biology

Mendelian randomization is a research method that uses genetic variations to study the causal effects of a modifiable exposure (like diet or lifestyle) on a disease. By leveraging the random assortment of genes from parents to offspring, it mimics the design of a randomized controlled trial, helping to determine whether an observed association between a risk factor and a health outcome is likely to be causal rather than due to confounding factors.

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research Effects of Lifelong Testosterone Exposure on Health and Disease Using Mendelian Randomization

29 citations, October 2020 in “eLife”

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

research Association Between Genetically Predicted Leukocyte Telomere Length and Non-Scarring Alopecia: A Two-Sample Mendelian Randomization Study

4 citations, January 2023 in “Frontiers in Immunology”

Shorter telomeres in white blood cells may increase the risk of a common type of hair loss.

Potential Therapeutic Targets for Androgenetic Alopecia in Obese Individuals Revealed by Gut Microbiome Analysis: A Mendelian Randomization Study

research Potential Therapeutic Targets for Androgenetic Alopecia in Obese Individuals Revealed by Gut Microbiome Analysis: A Mendelian Randomization Study

May 2025 in “Nutrients”

Gut bacteria pathways may help treat hair loss in obese people.

research Association Between Androgenic Alopecia and Schizophrenia: A Bidirectional Mendelian Randomization Study

April 2025 in “International Journal of Dermatology and Venereology”

Androgenetic alopecia may cause schizophrenia, but schizophrenia does not cause androgenetic alopecia.

Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis

research Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis

February 2025 in “Clinical Cosmetic and Investigational Dermatology”

Higher fasting insulin levels increase the risk of androgenetic alopecia.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 8 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.