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Glossary Mendelian randomization

uses genetic variations to infer causal relationships in biology

Mendelian randomization is a research method that uses genetic variations to study the causal effects of a modifiable exposure (like diet or lifestyle) on a disease. By leveraging the random assortment of genes from parents to offspring, it mimics the design of a randomized controlled trial, helping to determine whether an observed association between a risk factor and a health outcome is likely to be causal rather than due to confounding factors.

Research

5 / 797 results

research Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

29 citations , October 2020 in “eLife”

This study using Mendelian randomization in UK Biobank data suggests that lifelong increased free testosterone may have mixed effects, including increased bone density and prostate cancer risk, warranting well-powered trials to address uncertainties.

research Genetic links between atopy, allergy, and alopecia areata: insights from a Mendelian randomization study

11 citations , April 2024 in “Allergy Asthma and Clinical Immunology”

This study found compelling genetic evidence linking atopic and allergic conditions with the development of alopecia areata, suggesting a need for closer monitoring in affected individuals.

research Exploring the link between gut microbiota and alopecia areata: a two‐sample Mendelian randomization analysis

6 citations , January 2024 in “International Journal of Dermatology”

In this study, the researchers used Mendelian randomization to suggest a potential causal link between various gut microbiota and alopecia areata, finding that certain bacteria like Butyricimonas and Phascolarctobacterium may have protective effects, whereas others like Ruminococcaceae UCG003 might increase risk.

research The causal relationship between gut microbiota and alopecia areata: a Mendelian randomization analysis

5 citations , July 2024 in “Frontiers in Microbiology”

In this study, researchers using Mendelian randomization found a potential causal relationship between the gut microbiome and alopecia areata, with 16 gut microbial taxa showing links to the condition, though reverse causation results were not statistically significant.

research Autoimmune thyroid disease and human health: a systematic review of Mendelian randomization studies

4 citations , December 2025 in “Frontiers in Immunology”

This systematic review of Mendelian randomization studies reports that autoimmune thyroid disease is associated with increased risk for numerous health conditions, including coronary atherosclerosis and rheumatoid arthritis, while decreasing risks for others, such as lung cancer.

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Community Join

3 / 3 results

community Hair Loss Causes Depression. Not Finasteride.

187 upvotes 7 months ago

Finasteride and Dutasteride do not cause depression or mood disorders; hair loss itself may be a more significant factor. Some users experience side effects from Finasteride, but it is generally well-tolerated.

community Hair Loss Ruins Your Mind: 10x rate of BDD. PF S is not real

in Research/Science 39 upvotes 7 months ago

Hair loss is linked to a higher rate of body dysmorphic disorder (BDD), OCD, and depression. Finasteride and dutasteride are not linked to increased suicidal risk, though some users report mental health side effects.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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