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Glossary Randomized Controlled Trials

scientific studies comparing treatments by randomly assigning participants

Randomized Controlled Trials (RCTs) are scientific studies designed to test the effectiveness of medical treatments or interventions by randomly assigning participants to either a treatment group or a control group. This randomization helps eliminate bias, ensuring that any differences observed between the groups can be attributed to the treatment itself rather than other factors. RCTs are considered the gold standard in clinical research for establishing causality and assessing the efficacy and safety of new therapies.

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Research

5 / 1000+ results

research Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials

April 2026 in “Figshare”

This source reports that in adults with non-scarring alopecia, polyphenolic interventions significantly improved hair density and total area hair count compared to controls, although considerable variability was present in results, highlighting the need for further research.

research Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials

April 2026 in “Figshare”

This systematic review and meta-analysis found that polyphenolic interventions significantly improved hair density and total area hair count in adults with non-scarring alopecia, but substantial heterogeneity was observed.

research Efficacy of polyphenolic compounds for hair regeneration: a systematic review and meta-analysis of randomized controlled trials.

April 2026 in “PubMed”

This study evaluated the efficacy of polyphenolic compounds for hair growth in adults with non-scarring alopecia and found that these interventions significantly improved hair density and total area hair count compared to controls, although results were not significantly different from minoxidil.

research P06 Evaluating the efficacy and safety of combined microneedling therapy vs. topical minoxidil in androgenetic alopecia: a systematic review and meta-analysis of randomized controlled trials

January 2026 in “British Journal of Dermatology”

This study found that combined microneedling with minoxidil significantly improved hair count and diameter in patients with androgenetic alopecia compared to minoxidil alone, despite mild adverse events, and microneedling parameters like depth and duration did not significantly affect outcomes.

research 64082 Combined Minoxidil and Platelet-Rich Plasma Compared With Monotherapy in Androgenetic Alopecia: A Systematic Review and Meta-analysis of Randomized Controlled Trials

September 2025 in “Journal of the American Academy of Dermatology”

Combining minoxidil and PRP is more effective for hair growth than using either alone.

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Community Join

5 / 186 results

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

308 upvotes 1 year ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community Does creatine cause hair loss? A 12-week randomized controlled trial - PubMed

24 upvotes 1 year ago

Creatine does not directly cause hair loss, but it may increase DHT levels, which can affect hair. Some users report hair shedding with creatine, while others experience no hair loss.

community Korean Laser Helmet has a 44% increase in hair growth vs 0% growth in placebo in a double-blinded randomized controlled clinical trial.

3037 upvotes 11 months ago

A Korean laser helmet increases hair growth by 44% compared to a placebo. Users discuss its cost-effectiveness, clinical support, and compare it to treatments like finasteride and minoxidil, focusing on wavelength and energy density.

community Pumkin Seed Oil 400mg/day oral, 6 month Randomized, Double-Blind, Placebo-Controlled Trial (N=76)

4 upvotes 4 years ago

Pumpkin seed oil may increase hair count but not thickness, though its effectiveness is debated. Some suggest using topical finasteride or saw palmetto instead.

community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting

in Chat 30 upvotes 6 months ago

PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.

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Learn

5 / 20 results

learn Alfatradiol

Weak form of estrogen applied to the scalp

Alfatradiol: Can it help if my hair loss is linked to DHT? The one randomised trial of topical alfatradiol — in 103 women — found hair thickness and density essentially unchanged after six months, while minoxidil improved both; its authors credited alfatradiol with slowing hair loss, but the trial had no placebo group to test that. Laboratory work on isolated follicles suggests a local effect on DHT, but no controlled trial in men appears to have been published.

learn Ketoconazole

Antifungal, best known as a dandruff shampoo

learn HMI-115

Experimental antibody that blocks the prolactin receptor

learn Latanoprost

Prostaglandin eye drop used for glaucoma

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

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