A Review on Laser and Light-Based Therapies for Alopecia Areata

    Stephanie Mlacker, Adam S. Aldahan, Brian J. Simmons, Vidhi V. Shah, Colin A. McNamara, Sahal Samarkandy, Keyvan Nouri
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    TLDR Laser and light therapies, especially the 308 nm excimer laser, are effective and safe for treating alopecia areata, but more research is needed.
    The document from 2017 reviewed the effectiveness and safety of laser and light-based therapies for treating alopecia areata (AA), a type of hair loss caused by an autoimmune response. The excimer laser, particularly the 308 nm monochromatic excimer light (MEL), was highlighted as an effective treatment, with studies showing 60 to 77% improvement in hair regrowth. Other treatments such as diode lasers also showed promise, with one study reporting hair regrowth in 94% of treated patches among 16 patients. However, therapies like narrowband UVB phototherapy and Nd:YAG lasers had limited success or were confounded by factors like spontaneous remission or concurrent treatments. UVA-1 phototherapy was noted for its safety and significant improvement in a small study of 4 patients. Side effects of these therapies were generally mild. The review emphasized the need for more randomized controlled trials with larger patient numbers and longer follow-up periods to establish the long-term efficacy and safety of these treatments and called for a universal measure of hair growth to objectively compare different treatments.
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