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Glossary Clinical Trials

research studies testing new treatments or interventions on volunteers

Clinical trials, also known as clinical studies or clinical research, are research investigations in which people volunteer to test new treatments, interventions, or tests to prevent, detect, treat, or manage various diseases and medical conditions. These trials are conducted in phases, each designed to answer specific research questions while ensuring the safety and efficacy of the intervention.

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Research

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research Sublingual tofacitinib for alopecia areata: a roll‐over pilot clinical trial and analysis of pharmacokinetics

9 citations , May 2021 in “International Journal of Dermatology”

In this study, sublingual tofacitinib achieved a longer estimated half-life than oral administration in treatment-resistant alopecia areata patients, potentially supporting daily dosing; overall treatment response was modest.

research Evaluating statistics in clinical trials: Making the unintelligible intelligible

5 citations , October 2008 in “Australasian Journal of Dermatology”

This review aims to help medical practitioners understand inferential statistical methods to critically evaluate clinical trial design and analyses, but it doesn’t present new research findings.

research Development of Uniform Protocol for Alopecia Areata Clinical Trials

2 citations , November 2015 in “Journal of Investigative Dermatology Symposium Proceedings”

This article discusses the creation of Alopecia Areata Uniform Protocols by the National Alopecia Areata Foundation to standardize clinical trials for alopecia areata treatments and reports no new results.

research Evidence Based Hair Restoration: Designing Clinical Trials

1 citations , May 2006 in “Hair transplant forum international”

This article discusses the principles of Evidence-Based Medicine (EBM) in patient care decision-making and reports no new empirical findings.

research Clinical Trials and Hair Loss

1 citations , July 2018 in “Elsevier eBooks”

This review explores the current treatments for different types of alopecia, emphasizing the need for well-designed clinical trials and highlighting that most therapies are used off-label, as only androgenetic alopecia has FDA-approved drugs.

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Community Join

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community Clinical Trial: N-Acetyl-Cysteine for Treatment of AGA in Men

5 upvotes 5 years ago

N-Acetyl-Cysteine (NAC) is being explored for treating hair loss, but users report mixed results. Some also mention using Quercetin and Resveratrol without significant hair improvement.

community $20,000 reimbursement to participate in a Hair Loss Clinical Trial (in Australia) that could grow back your hair and reverse grey hair if successful.

in Research/Science 188 upvotes 7 months ago

A clinical trial in Australia offers $20,000 for participation, aiming to regrow hair and reverse grey hair. Participants must not have used hair treatments recently and must visit a Melbourne clinic regularly over 18 months.

community Verteporfin Phase 1 Human Clinical Trial In The Works

in Research 137 upvotes 1 year ago

Verteporfin human clinical trials for hair loss may start in 2025. Additional resources and presentations are available for more information.

community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

156 upvotes 1 year ago

GT20029 and KX826 are promising hair loss treatments, with GT20029 increasing hair count and KX826 showing significant results. KX826 may be a good alternative for those who can't use finasteride or dutasteride, though results vary.

community Pyrilutamide phase III clinical trial results released

in Research/Science 31 upvotes 2 years ago

Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

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Learn

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learn SCUBE3

What do clinical trials say about the safety and effectiveness of SCUBE3 for hair regrowth? No clinical trial of SCUBE3 for hair regrowth has been registered on ClinicalTrials.gov or published, so there is no human safety or effectiveness data. The evidence is limited to one 2022 laboratory and mouse study reporting that SCUBE3 activates hair follicle stem cells through TGF-beta signalling.

learn GT20029

When will GT20029 be commercially available, and are there any clinical trials on its use? GT20029 is investigational and not approved or sold anywhere. A published 12-week Phase II study in 180 Chinese men reports hair-count gains over placebo with two of four regimens, but no long-term or Phase III data exists, so any launch is years away at best.

learn Follistatin

Protein that blocks activin, a growth-regulating signal

Are there any clinical studies supporting follistatin as a hair loss treatment? There is no controlled human trial showing follistatin treats hair loss; the published work is mouse and laboratory biology on the activin/follistatin signalling system, plus one small 2011 phase 1 injection study of a combination product, so follistatin remains experimental and unapproved.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Stem Cell Factor

Can stem cell factor be combined with other topical hair loss solutions? No published human trial has tested topical stem cell factor alongside minoxidil or other established treatments, so neither the safety nor the benefit of the combination has been established. Community users report layering these products, but that is anecdote rather than clinical evidence.