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Did you mean Placebo-Controlled?

Glossary Placebo-Controlled

comparison involves an inactive substance to test treatment efficacy

A placebo-controlled study is a type of clinical trial where one group of participants receives the experimental treatment, while another group receives a placebo—a substance with no therapeutic effect, often a sugar pill. This design helps researchers determine the actual effectiveness of the treatment by comparing outcomes between the treated group and the placebo group, thereby accounting for the placebo effect, where participants may experience perceived or actual improvements in their condition simply because they believe they are receiving treatment.

Related Terms

Research

5 / 1000+ results

research A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

In this 48-week trial, 5% topical minoxidil was more effective than both 2% minoxidil and placebo in promoting hair growth in women with female pattern hair loss, with notable improvements in nonvellus hair count and hair growth assessments.

research Safety and efficacy of ALRV5XR in women with androgenetic alopecia or telogen effluvium: A randomised, double-blinded, placebo-controlled clinical trial

6 citations , June 2021 in “EClinicalMedicine”

In this study, ALRV5XR significantly increased hair regrowth in women with androgenetic alopecia or telogen effluvium, with no adverse events reported.

research Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: A randomized, placebo‐controlled trial

7 citations , December 2020 in “Dermatologic Therapy”

In this study, intradermal injections of 0.5% minoxidil significantly improved hair growth and volume in women with female androgenetic alopecia compared to a placebo, with a good safety profile reported.

research A randomized, placebo-controlled trial of 1% topical minoxidil solution in the treatment of androgenetic alopecia in Japanese women.

10 citations , May 2007 in “PubMed”

This study found that 1% topical minoxidil significantly increased hair count and improved hair growth perception among Japanese women with androgenetic alopecia compared to placebo.

research Efficacy and Safety of Low-Molecular-Weight Collagen Peptide GT for Improving Hair Condition in Individuals with Damaged Hair: A Randomized, Double-Blind, Placebo-Controlled Trial

August 2026 in “International Journal of Stem Cells”

In this study, Korean adults with damaged hair who took 3g/day of low-molecular-weight collagen peptide GT for 24 weeks showed significant improvements in hair gloss, elasticity, and scalp elasticity compared to placebo, without any adverse events.

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Community Join

5 / 876 results

community Korean Laser Helmet has a 44% increase in hair growth vs 0% growth in placebo in a double-blinded randomized controlled clinical trial.

3037 upvotes 11 months ago

A Korean laser helmet increases hair growth by 44% compared to a placebo. Users discuss its cost-effectiveness, clinical support, and compare it to treatments like finasteride and minoxidil, focusing on wavelength and energy density.

community Pumkin Seed Oil 400mg/day oral, 6 month Randomized, Double-Blind, Placebo-Controlled Trial (N=76)

4 upvotes 4 years ago

Pumpkin seed oil may increase hair count but not thickness, though its effectiveness is debated. Some suggest using topical finasteride or saw palmetto instead.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

308 upvotes 1 year ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community Reason why placebo group got regrow on trial phase 3

in Chat 16 upvotes 2 years ago

Placebo hair regrowth might be influenced by propylene glycol in lotions or participants lying about using other treatments like minoxidil, finasteride, or microneedling. Being part of a study can also improve hair health due to lifestyle changes.

community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting

in Chat 30 upvotes 6 months ago

PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.

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Learn

8 / 22 results

learn Fluridil

Can daily Fluridil application stop hair follicle miniaturization? The single published fluridil trial (43 men; placebo-controlled for 3 months, then all on fluridil to 9 months) reported more hairs in the growth phase, but it never measured follicle diameter and has not been replicated — so whether daily use stops miniaturization is unproven, and community users describe stabilization rather than regrowth.

learn Melatonin

Melatonin: Does it work the same for men and women? No trial has compared melatonin's effect on hair in men versus women. The only placebo-controlled scalp study enrolled 40 women, and the single reported sex difference — shedding fell in women but not men — comes from one uncontrolled 60-person observation, so any difference is unestablished.
Melatonin: Can it be combined with other treatments like minoxidil or Redensyl? No published trial has tested melatonin together with minoxidil or Redensyl, and no interaction study exists — so the combination is untested rather than shown to be safe. The melatonin scalp evidence on its own is one small placebo-controlled trial plus several uncontrolled studies.

learn Alfatradiol

Weak form of estrogen applied to the scalp

Does Alfatradiol work the same for women, men, and trans people? Almost all controlled data on topical alfatradiol comes from cisgender women, where hair density and thickness stayed nearly unchanged over 6 months while minoxidil improved them (the trial had no placebo group). No published controlled trial covers cisgender men, and none covers trans people at all — so the honest answer is that the difference has not been measured.

learn Procyanidin

Can Procyanidin supplements taken orally help strengthen existing hair and prevent shedding? One 2-month trial of an apple-extract supplement from the study authors' own group (250 adults, no parallel placebo group) reported more hair growth compared with each person's starting point. Oral procyanidin has not been shown in a placebo-controlled comparison to strengthen hair or prevent shedding.

learn HMI-115

Experimental antibody that blocks the prolactin receptor

learn Latanoprost

Prostaglandin eye drop used for glaucoma

learn Metformin

Diabetes drug that lowers blood sugar

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

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