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    Melatonin

    Melatonin is an indoleamine compound produced by various organisms, including bacteria and eukaryotes. It was discovered in 1958 by Aaron B. Lerner and colleagues in substance from the pineal gland of cows that could induce skin lightening in common frogs. The secretion of melatonin is influenced by the circadian rhythm, and it plays a role in regulating the sleep-wake cycle in vertebrates.

    Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

    Research 10

    1. Topical Melatonin in the Treatment of Hair Loss (Alopecia): A Comprehensive Scientific Review DOAJ (DOAJ: Directory of Open Access Journals) · 2026
    2. Restoring natural hair pigmentation: clinical assessment of safety and efficacy of an ayurvedic leave-on treatment International Journal of Research in Dermatology · 2025
    3. Managing patterned hair loss – a hair raising task! Cosmoderma · 2021
    4. Cosmetic Considerations in Dark-Skinned Patients Clinical, cosmetic and investigational dermatology · 2024
    5. A comparative study of histopathologic features in alopecia areata and pattern hair loss Journal of Cutaneous Pathology · 2023
    6. Mitigation of epidermal growth factor receptor inhibitor-induced side effects utilizing melanin and vascular-specific lasers: A case report series Journal of cosmetic and laser therapy · 2017 · 1 citations
    7. Loss of ‘Epidermal Melanin Unit’ Integrity in Human Skin During Melanoma-Genesis Frontiers in oncology · 2022 · 13 citations
    8. Clinical efficacy of silk sericin dressing with collagen for split-thickness skin graft donor site treatment 2021
    9. White Hair–Induced Increased Scalp Visibility: Clinical Implications for Hair Loss Evaluation and Hair Transplantation Clinical Cosmetic and Investigational Dermatology · 2026
    10. Adult‐onset hair loss in Chesapeake Bay retrievers: a clinical and histological study Veterinary dermatology · 2005 · 8 citations
    All research on Melatonin →

    Community 10

    1. Anyone try the 4 in 1 Spray w/ Minoxidil 5%, Caffeine .2%, Melatonin .1%, Tretinoin .01% (81 G)? Reddit · 4 Jan 2026
    2. Reminder to add melatonin to your topical solutions (or to min if you take fin orally) Reddit · 1 Dec 2023
    3. DIY Minoxidil mix with Fin, Caffeine, Cetirizine, and Melatonin? Reddit · 12 Jun 2025
    4. Topical melatonin shows some promise. Reddit · 1 Jul 2016
    5. Anyone had luck with one of those minoxidil + tretinoin + caffeine + melatonin sprays? Reddit · 7 May 2025
    6. Melatonin emerging as new treatment for androgenic alopecia? Reddit · 14 Dec 2024
    7. What about this? Topical minoxidil, caffein, melatonin + keto + saw palmetto Reddit · 24 Feb 2025
    8. Anyone try a combo therapy of everything except fin? Minox + Tret + microneedling + caffeine, etc Reddit · 2 Sept 2024
    9. Thoughts of this sub on Melatonin? Reddit · 17 Feb 2025
    10. What melatonin product are you using? Are you making your own solution? Reddit · 13 Sept 2024
    All community posts on Melatonin →