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    Melatonin

    Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs. This compound was later identified as a hormone secreted in the brain during the night, playing a crucial role in regulating the sleep-wake cycle, also known as the circadian rhythm, in vertebrates.

    Information, not medical advice. Talk to a licensed doctor or pharmacist before starting or changing a treatment.

    Research 10

    1. Topical Melatonin in the Treatment of Hair Loss (Alopecia): A Comprehensive Scientific Review DOAJ (DOAJ: Directory of Open Access Journals) · 2026
    2. Restoring natural hair pigmentation: clinical assessment of safety and efficacy of an ayurvedic leave-on treatment International Journal of Research in Dermatology · 2025
    3. Managing patterned hair loss – a hair raising task! Cosmoderma · 2021
    4. Cosmetic Considerations in Dark-Skinned Patients Clinical, cosmetic and investigational dermatology · 2024
    5. A comparative study of histopathologic features in alopecia areata and pattern hair loss Journal of Cutaneous Pathology · 2023
    6. Mitigation of epidermal growth factor receptor inhibitor-induced side effects utilizing melanin and vascular-specific lasers: A case report series Journal of cosmetic and laser therapy · 2017 · 1 citations
    7. Loss of ‘Epidermal Melanin Unit’ Integrity in Human Skin During Melanoma-Genesis Frontiers in oncology · 2022 · 13 citations
    8. Clinical efficacy of silk sericin dressing with collagen for split-thickness skin graft donor site treatment 2021
    9. White Hair–Induced Increased Scalp Visibility: Clinical Implications for Hair Loss Evaluation and Hair Transplantation Clinical Cosmetic and Investigational Dermatology · 2026
    10. Adult‐onset hair loss in Chesapeake Bay retrievers: a clinical and histological study Veterinary dermatology · 2005 · 8 citations
    All research on Melatonin →

    Community 10

    1. Anyone try the 4 in 1 Spray w/ Minoxidil 5%, Caffeine .2%, Melatonin .1%, Tretinoin .01% (81 G)? Reddit · 4 Jan 2026
    2. Reminder to add melatonin to your topical solutions (or to min if you take fin orally) Reddit · 1 Dec 2023
    3. DIY Minoxidil mix with Fin, Caffeine, Cetirizine, and Melatonin? Reddit · 12 Jun 2025
    4. Topical melatonin shows some promise. Reddit · 1 Jul 2016
    5. Anyone had luck with one of those minoxidil + tretinoin + caffeine + melatonin sprays? Reddit · 7 May 2025
    6. Melatonin emerging as new treatment for androgenic alopecia? Reddit · 14 Dec 2024
    7. What about this? Topical minoxidil, caffein, melatonin + keto + saw palmetto Reddit · 24 Feb 2025
    8. Anyone try a combo therapy of everything except fin? Minox + Tret + microneedling + caffeine, etc Reddit · 2 Sept 2024
    9. Thoughts of this sub on Melatonin? Reddit · 17 Feb 2025
    10. What melatonin product are you using? Are you making your own solution? Reddit · 13 Sept 2024
    All community posts on Melatonin →