Melatonin
Where to find Melatonin
Tracking 1 topical product and 1 raw product by companies like Anageninc and MinoxidilMax. View all 2 products »Melatonin, a hormone synthesized primarily by the pineal gland in the brain, is well-known for its role in regulating sleep-wake cycles and circadian rhythms. Beyond these functions, melatonin has been explored for its antioxidant, anti-inflammatory, and possibly anti-androgenic properties, making it a compound of interest in various medical and cosmetic fields, including hair health.
Numerous peripheral organs, including human skin and hair follicles, not only respond to melatonin's bioactivity but also synthesize, regulate, and metabolize it extrapineally. Human skin possesses a complete melatoninergic enzyme system necessary for melatonin biosynthesis, alongside functional melatonin receptors in keratinocytes, melanocytes, and fibroblasts, which contribute to cellular proliferation, differentiation, and protection against UV-induced damage through an active antioxidative system. Similarly, human hair follicles synthesize melatonin, express melatonin receptors, and demonstrate an influence on hair growth cycles. In vitro studies show that melatonin at a concentration significantly accelerates hair follicle growth, likely through a receptor-mediated mechanism, as this stimulation can be inhibited by a potent melatonin antagonist.
In the context of alopecia and hair growth, melatonin has garnered attention for its potential to promote hair follicle health and hair growth. This interest is partly due to melatonin's antioxidant properties, which can combat oxidative stress in hair follicles, yielding protective and anti-apoptotic effects against factors that contribute to hair aging and loss. Additionally, some research suggests that melatonin might modulate the hair growth cycle, potentially extending the anagen (growth) phase and enhancing hair density and thickness. Studies have explored topical applications of melatonin on the scalp, showing promising results in increasing anagen hair rate in individuals with androgenetic alopecia or diffuse alopecia, suggesting its utility as a novel treatment for hair loss. A double-blind, placebo-controlled pilot study where topical application of a 0.1% melatonin-alcohol solution significantly increased the number of anagen hairs in women with AGA and diffuse alopecia after six months, underscoring melatonin's potential in hair growth stimulation.
The community's sentiment towards melatonin as a hair growth treatment is generally positive, with individuals sharing their experiences and observations of improved hair health after incorporating melatonin into their hair care routines. Many discuss using topical melatonin solutions, often in conjunction with other treatments like minoxidil, to tackle hair loss. Anecdotal reports include increases in hair density and overall scalp health, with some users specifically highlighting melatonin's ease of use and lack of significant side effects as major advantages.
The positive community feedback and preliminary scientific evidence suggest that melatonin could be a valuable addition to hair loss treatment regimens, offering a novel approach to enhancing hair growth and scalp health.
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2 resultsResearch
20 / 1000+ results![Melatonin membrane receptors in peripheral tissues: Distribution and functions](/images/research/fae5a9a1-a612-40f8-a864-e0942104363c/small/14663.jpg)
research Melatonin membrane receptors in peripheral tissues: Distribution and functions
![Melatonin in the skin: synthesis, metabolism and functions](/images/research/8989fb0f-f723-4c8c-ab4f-09156826a261/small/15090.jpg)
research Melatonin in the skin: synthesis, metabolism and functions
![On the Role of Melatonin in Skin Physiology and Pathology](/images/research/a0fb2e79-2605-43fa-8350-3f28097dc2da/small/34987.jpg)
research On the Role of Melatonin in Skin Physiology and Pathology
![MELATONIN](/images/research/b7549ba5-6f0f-41d7-9164-7534599e47d0/small/35046.jpg)
research MELATONIN
![Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions](/images/research/07ebd437-bdeb-47f3-a33a-d1dd9f936191/small/17983.jpg)
research Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions
research Melatonin: functions and ligands
research Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair
![Melatonin and the hair follicle](/images/research/f3ad7c3a-f9d3-4ab4-a752-9b9d0e286d82/small/34973.jpg)
research Melatonin and the hair follicle
![Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial](/images/research/fea6c9c2-556d-4ad5-aa83-ce7067ca56d2/small/2526.jpg)
research Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial
![Murine skin as a target for melatonin bioregulation](/images/research/03d39b55-6591-4140-b816-f0df135bd037/small/35032.jpg)
research Murine skin as a target for melatonin bioregulation
![Ultrastructural evaluation of the radioprotective effects of melatonin against X‐ray‐induced skin damage in Albino rats](/images/research/1589179a-6e19-4997-9627-fe0773b2e517/small/34991.jpg)
research Ultrastructural evaluation of the radioprotective effects of melatonin against X‐ray‐induced skin damage in Albino rats
![Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane](/images/research/0ef8a8ed-8b75-4703-8bd5-2cace3aba1fd/small/34994.jpg)
research Adrenal steroid hormone concentrations in dogs with hair cycle arrest (Alopecia X) before and during treatment with melatonin and mitotane
![Effect of constant-release melatonin implants and prolonged exposure to a long day photoperiod on prolactin secretion and hair growth in mouflon (Ovis gmelini musimon)](/images/research/9e320cde-33bd-4e42-b6e3-58de9c12c29c/small/34995.jpg)
research Effect of constant-release melatonin implants and prolonged exposure to a long day photoperiod on prolactin secretion and hair growth in mouflon (Ovis gmelini musimon)
research Fiber growth initiation in hair follicles of goats treated with melatonin
![Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis](/images/research/e13111e3-be0e-4327-b487-d911b0ddabf2/small/26491.jpg)
research Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis
![Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial](/images/research/56b7ae03-ea47-4147-b333-eef9c28174f6/small/13484.jpg)
research Effects of melatonin administration on mental health parameters, metabolic and genetic profiles in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial
![Protective Effects of Melatonin on the Skin: Future Perspectives](/images/research/db328c06-a3f8-4647-8c19-923debfdccf6/small/13372.jpg)
research Protective Effects of Melatonin on the Skin: Future Perspectives
![Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats](/images/research/adb4a50a-aece-46e4-9625-ab291bdfb1c5/small/14413.jpg)
research Protective effects of melatonin against metabolic and reproductive disturbances in polycystic ovary syndrome in rats
research Melatonin vitamin C-based nanovesicles for treatment of androgenic alopecia: Design, characterization and clinical appraisal
![Topical Melatonin for Treatment of Androgenetic Alopecia](/images/research/4b9d2854-89ff-4ccf-a995-0d00787d031e/small/3221.jpg)