Melatonin: A Cutaneous Perspective on Its Production, Metabolism, and Functions

    Andrzej Słomiński, Ruediger Hardeland, Michał A. Żmijewski … Ralf Paus
    Studysummary This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 21

    1. Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond? BioEssays · 2017
    2. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    3. When The Circadian Clock Meets The Melanin Pigmentary System Journal of Investigative Dermatology · 2015
    4. The Peripheral Clock Regulates Human Pigmentation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2014
    5. Melatonin: Functions and Ligands Drug discovery today · 2014
    6. A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock Journal of Investigative Dermatology · 2013
    7. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012
    8. Differential Effects of Melatonin as a Broad Range UV-Damage Preventive Dermato-Endocrine Regulator Dermato-endocrinology · 2011
    9. Melatonin as a Major Skin Protectant: From Free Radical Scavenging to DNA Damage Repair Experimental dermatology · 2008
    10. Melatonin in the Skin: Synthesis, Metabolism, and Functions Trends in Endocrinology and Metabolism · 2008
    11. Melatonin and the Hair Follicle Journal of pineal research · 2007
    12. The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors ˜The œFASEB journal · 2005
    13. The Cutaneous Serotoninergic/Melatoninergic System: Securing a Place Under the Sun ˜The œFASEB journal · 2005
    14. On the Role of Melatonin in Skin Physiology and Pathology Endocrine journal · 2005
    15. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    16. Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial British Journal of Dermatology · 2004
    17. Characterization of the Serotoninergic System in the C57BL/6 Mouse Skin European journal of biochemistry · 2003
    18. Serotoninergic And Melatoninergic Systems Are Fully Expressed In Human Skin ˜The œFASEB journal · 2002
    19. Cellular And Developmental Aspects Of Androgenetic Alopecia Experimental Dermatology · 1998
    20. Murine Skin as a Target for Melatonin Bioregulation Experimental dermatology · 1994
    21. On the Etiology of Vitiligo and Gray Hair The American Journal of Medicine · 1971