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research Melatonin-Mediated Circadian Rhythm Signaling Exhibits Bidirectional Regulatory Effects on the State of Hair Follicle Stem Cells

February 2025 in “Biomolecules”

This research found that melatonin has a bidirectional effect on hair follicle stem cell survival, improving it at low doses and inhibiting it at high doses.

research Beyond Circadian Rhythm: Melatonin as a Bio-Regulatory Molecule in Skin and Hair Aesthetics

March 2026 in “International Journal of Science and Research (IJSR)”

This study reviews melatonin's diverse roles in dermatology, highlighting its potential to protect skin from UV damage and oxidative stress, enhance DNA repair, and influence hair follicle cycling, suggesting therapeutic applications in skin care and hair renewal.

research Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator

31 citations , January 2011 in “Dermato-endocrinology”

This review updates the protective effects and molecular mechanisms of melatonin against ultraviolet-induced damage in human skin, reporting no new clinical findings.

research Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions

185 citations , February 2018 in “Journal of Investigative Dermatology”

This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.

research When the Circadian Clock Meets the Melanin Pigmentary System

18 citations , March 2015 in “Journal of Investigative Dermatology”

In this study, silencing BMAL1 and PER1 genes increased melanogenic activity in follicular and epidermal melanocytes, suggesting that peripheral circadian clocks may regulate melanin pigmentation.

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Community Join

5 / 15 results

community Does Creatine Really Increase DHT? My Personal Experiment

115 upvotes 1 year ago

Creatine does not increase DHT levels, but some report hair loss when using it, possibly due to other factors. The effects on hair loss vary individually, with no clear connection established.

community 6 months into Dutasteride and my hair is way worse than before

in Finasteride/Dutasteride 70 upvotes 2 years ago

After six months on Dutasteride, the user's hair is worse than before, despite previously trying finasteride and RU/Fluridil without success. Some suggest continuing Dutasteride and adding progress photos, while others share their positive experiences or advise sticking to one treatment for at least a year.

community I cannot sleep anymore, what should I do

7 upvotes 1 year ago

Finasteride may cause sleep disturbances, with some users experiencing insomnia. Reducing the dosage, switching brands, or trying Dutasteride might help.

community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community How long does it take after an environmental / lifestyle change for hair loss to actually slow down?

5 upvotes 11 months ago

Lifestyle changes may not significantly impact hair loss, as factors like DHT and genetics play a larger role. Some users suggest treatments like finasteride, dutasteride, and microneedling for hair growth.

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Learn

1 / 801 results

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

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Trichology
Hair Rhythm Hair Restoration SalonKato · JP

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