A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

September 2013 in “ Journal of Investigative Dermatology ”

Yusur Al‐Nuaimi, J. Hardman, Tamás Bı́ró, Iain S. Haslam, Terence Kealey, Balázs István Tóth, Nilofer Farjo, Bessam Farjo, Gerold Baier, Rachel Watson, Benedetto Grimaldi, Jennifer E. Kloepper, Ralf Paus

circadian proteins Period1 BMAL1 human hair follicles core clock genes CLOCK c-Myc NR1D1 CDKN1A hair cycle phase anagen phase knockdown experiments peripheral core clock genes hair growth hair follicles hair cycle

Studysummary This study found that peripheral clock genes, particularly BMAL1 and Period1, modulate human hair follicle cycling, suggesting their potential as therapeutic targets for affecting hair growth.

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The study demonstrated that circadian proteins PER1 and BMAL1 significantly modulated the human hair cycle, particularly the transition from the growth phase (anagen) to the regression phase (catagen). In organ-cultured human hair follicles (HFs), silencing BMAL1 or PER1 prolonged the anagen phase, suggesting these genes as potential therapeutic targets for influencing hair growth. The research indicated that peripheral core clock genes were integral to the human hair cycle clock, offering insights into potential treatments for hair growth disorders. The study involved a small sample size, with scalp skin and HF units collected from 3 females and 10 males.

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