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research Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival

237 citations , February 2016 in “Science Translational Medicine”

This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.

research A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock

92 citations , September 2013 in “Journal of Investigative Dermatology”

This study found that peripheral clock genes, particularly BMAL1 and Period1, modulate human hair follicle cycling, suggesting their potential as therapeutic targets for affecting hair growth.

research The circadian molecular clock creates epidermal stem cell heterogeneity

293 citations , November 2011 in “Nature”

This study found that the circadian clock regulates the activation state of murine epidermal stem cells, affecting tissue homeostasis and susceptibility to tumorigenesis when disrupted.

research Circadian clocks: from stem cells to tissue homeostasis and regeneration

84 citations , December 2017 in “EMBO Reports”

This review discusses the role of circadian rhythms in stem cell differentiation and tissue regeneration, emphasizing their impact on organ physiology and aging, but reports no new experimental results.

research Thyroxine Differentially Modulates the Peripheral Clock: Lessons from the Human Hair Follicle

30 citations , March 2015 in “PLoS ONE”

This study found that thyroxine modulates peripheral molecular clock gene expression in human hair follicles, which may have implications for treating clock-related diseases in patients with thyroid dysfunction.

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community Other factors involved then DHT/5aR

5 upvotes 3 months ago

DHT is the primary cause of hair loss, but factors like diet, stress, and lifestyle can influence its severity. Treatments like finasteride and dutasteride target DHT, while maintaining overall health is also important.

community PP405 Drug in Action: Picture From Official Company Website

780 upvotes 1 year ago

PP405 shows promise for hair follicle reactivation with minimal side effects. Users recommend continuing Minoxidil and Finasteride until more results are confirmed.

community Sublingual Minoxidil - Cure to Hairloss?

in Minoxidil 583 upvotes 2 years ago

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

community I understand this topic has been discussed countless times, but hair loss is the most brutal experience for men.

in Chat 343 upvotes 1 year ago

Hair loss significantly affects men's confidence and mental health. Common treatments include finasteride, dutasteride, and minoxidil, with some considering hair transplants.

community 6 Months Into Dut Progress Pictures

102 upvotes 1 year ago

Switching from finasteride to dutasteride caused significant shedding but minimal side effects. The user plans to continue dutasteride for 12 months despite concerns about hair density.

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi