Thyroxine Differentially Modulates the Peripheral Clock: Lessons from the Human Hair Follicle

March 2015 in “ PLoS ONE ”

J. Hardman, Iain S. Haslam, Nilofer Farjo, Bessam Farjo, Ralf Paus

thyroxine T4 human hair follicles peripheral clock clock genes BMAL1 PER1 epithelial stem cells thyroid dysfunction circadian activity thyroid hormone hair follicles body clock stem cells

Studysummary This study found that thyroxine modulates peripheral molecular clock gene expression in human hair follicles, which may have implications for treating clock-related diseases in patients with thyroid dysfunction.

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This study found that peripheral clock genes, particularly BMAL1 and Period1, modulate human hair follicle cycling, suggesting their potential as therapeutic targets for affecting hair growth.

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research Corrigendum to “Endocrine Controls of Primary Adult Human Stem Cell Biology: Thyroid Hormones Stimulate Keratin 15 Expression, Apoptosis, and Differentiation in Human Hair Follicle Epithelial Stem Cells In Situ and In Vitro”

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research Endocrine Controls of Primary Adult Human Stem Cell Biology: Thyroid Hormones Stimulate Keratin 15 Expression, Apoptosis, and Differentiation in Human Hair Follicle Epithelial Stem Cells In Situ and In Vitro

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research The Cycling Hair Follicle as an Ideal Systems Biology Research Model

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research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

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