Thyroxine Differentially Modulates the Peripheral Clock: Lessons from the Human Hair Follicle

    March 2015 in “ PLoS ONE ”
    J. Hardman, Iain S. Haslam, Nilofer Farjo … Ralf Paus
    Studysummary This study found that thyroxine modulates peripheral molecular clock gene expression in human hair follicles, which may have implications for treating clock-related diseases in patients with thyroid dysfunction.
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    Research cited in this study 16

    1. The Peripheral Clock Regulates Human Pigmentation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2014
    2. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    3. A Meeting of Two Chronobiological Systems: Circadian Proteins Period1 and BMAL1 Modulate the Human Hair Cycle Clock Journal of Investigative Dermatology · 2013
    4. Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles Journal of Investigative Dermatology · 2013
    5. Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling Proceedings of the National Academy of Sciences of the United States of America · 2013
    6. Corrigendum to “Endocrine Controls of Primary Adult Human Stem Cell Biology: Thyroid Hormones Stimulate Keratin 15 Expression, Apoptosis, and Differentiation in Human Hair Follicle Epithelial Stem Cells In Situ and In Vitro” European Journal of Cell Biology · 2012
    7. Brain And Muscle Arnt-Like Protein-1 (BMAL1) Controls Circadian Cell Proliferation And Susceptibility To UVB-Induced DNA Damage In The Epidermis Proceedings of the National Academy of Sciences of the United States of America · 2012
    8. Noninvasive Method for Assessing the Human Circadian Clock Using Hair Follicle Cells Proceedings of the National Academy of Sciences of the United States of America · 2010
    9. Endocrine Controls of Primary Adult Human Stem Cell Biology: Thyroid Hormones Stimulate Keratin 15 Expression, Apoptosis, and Differentiation in Human Hair Follicle Epithelial Stem Cells In Situ and In Vitro European Journal of Cell Biology · 2010
    10. The Cycling Hair Follicle as an Ideal Systems Biology Research Model Experimental Dermatology · 2010
    11. Clock Genes, Hair Growth, and Aging Aging · 2010
    12. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    13. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    14. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
    15. Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle British journal of dermatology/British journal of dermatology, Supplement · 2000
    16. Human Hair Growth In Vitro Journal of Cell Science · 1990

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