Endocrine Controls of Primary Adult Human Stem Cell Biology: Thyroid Hormones Stimulate Keratin 15 Expression, Apoptosis, and Differentiation in Human Hair Follicle Epithelial Stem Cells In Situ and In Vitro

    July 2010 in “ European Journal of Cell Biology ”
    Stephan Tiede, Kirsten Böhm, N. Meier … Ralf Paus
    Studysummary This study found that thyroid hormones T3 and T4 enhance keratin 15 promoter activity and stimulate CD200 expression in epithelial stem cells from human scalp hair follicles, affecting their growth and differentiation.
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    Research cited in this study 16

    1. Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ The FASEB Journal · 2010
    2. Nonviral In Situ Green Fluorescent Protein Labeling and Culture of Primary, Adult Human Hair Follicle Epithelial Progenitor Cells Stem Cells · 2009
    3. Endocrine Controls of Keratin Expression BioEssays · 2009
    4. Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation The Journal of Clinical Endocrinology & Metabolism · 2008
    5. Neuroendocrinology of Epithelial Hair Follicle Stem Cells Molecular and Cellular Endocrinology · 2008
    6. The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008
    7. Hair Follicle Stem Cells: Walking the Maze European Journal of Cell Biology · 2007
    8. Therapeutic Strategies for Treating Hair Loss Drug Discovery Today: Therapeutic Strategies · 2006
    9. Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    10. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    11. Sgk3 Links Growth Factor Signaling to Maintenance of Progenitor Cells in the Hair Follicle The Journal of Cell Biology · 2005
    12. Topical Thyroid Hormone Accelerates Wound Healing in Mice Endocrinology · 2005
    13. A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control ˜The œAmerican journal of pathology (Print) · 2005
    14. Expression of Hypothalamic-Pituitary-Thyroid Axis Related Genes in Human Skin Journal of Investigative Dermatology · 2002
    15. Thyroid Hormone Receptor β1 Is Expressed in the Human Hair Follicle British journal of dermatology/British journal of dermatology, Supplement · 2000
    16. Human Hair Growth In Vitro Journal of Cell Science · 1990

    Related research 7

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    2. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    3. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    4. Keratins of the Human Hair Follicle International review of cytology · 2005
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    6. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    7. The Extraction And Characterization Of Human Nail Keratin Journal of Dermatological Science · 1991