Endocrine Controls of Keratin Expression

March 2009 in “ BioEssays ”

Yuval Ramot, Ralf Paus, Stephan Tiede, Abraham Zlotogorski

keratin endocrine controls thyroid hormones glucocorticoids retinoic acid vitamin D neuroendocrine mediators intracutaneous keratin expression epidermal keratins hair keratins

TLDR Hormones control keratin production in skin and hair.

The review article discussed the critical role of endocrine controls in the expression of keratins, which are essential intermediate filaments in skin physiology. It highlighted that keratin gene and protein expression in mammalian skin are tightly regulated by various hormones, including thyroid hormones, glucocorticoids, retinoic acid, vitamin D, and neuroendocrine mediators. Understanding these endocrine controls is crucial for gaining insights into normal skin and hair function and could lead to new therapeutic approaches for various skin and hair diseases.

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Research cited in this study

21 / 21 results

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

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Endocrine Controls of Keratin Expression

Research cited in this study

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Neuroendocrinology of Epithelial Hair Follicle Stem Cells

research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

research Frontiers in the Neuroendocrine Controls of Hair Growth

research Prostanoid Receptors in Anagen Human Hair Follicles

research Prostaglandin Metabolism in Human Hair Follicle

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Human Hair Follicles Are an Extrarenal Source and a Nonhematopoietic Target of Erythropoietin

research Hair Follicle-Specific Keratins And Their Diseases

research The Hair Follicle as an Estrogen Target and Source

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

research Substantial Sex-Dependent Differences in the Response of Human Scalp Hair Follicles to Estrogen Stimulation In Vitro Advocate Gender-Tailored Management of Female Versus Male Pattern Balding

research Hirsutism and the Variable Response of the Pilosebaceous Unit to Androgens

research Human Hair Keratin-Associated Proteins

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research The Keratins and Their Disorders

research The Human Skin as a Hormone Target and an Endocrine Gland

research Vitamin D3 Analogs Stimulate Hair Growth in Nude Mice

research The Catalog of Human Hair Keratins

research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A

research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

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