Endocrine Controls of Keratin Expression

March 2009 in “ BioEssays ”

Yuval Ramot, Ralf Paus, Stephan Tiede, Abraham Zlotogorski

keratin endocrine controls thyroid hormones glucocorticoids retinoic acid vitamin D neuroendocrine mediators intracutaneous keratin expression epidermal keratins hair keratins

TLDR Hormones control keratin production in skin and hair.

The review article discussed the critical role of endocrine controls in the expression of keratins, which are essential intermediate filaments in skin physiology. It highlighted that keratin gene and protein expression in mammalian skin are tightly regulated by various hormones, including thyroid hormones, glucocorticoids, retinoic acid, vitamin D, and neuroendocrine mediators. Understanding these endocrine controls is crucial for gaining insights into normal skin and hair function and could lead to new therapeutic approaches for various skin and hair diseases.

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