Endocrine Controls of Keratin Expression

March 2009 in “ BioEssays ”

Yuval Ramot, Ralf Paus, Stephan Tiede, Abraham Zlotogorski

keratin endocrine controls thyroid hormones glucocorticoids retinoic acid vitamin D neuroendocrine mediators intracutaneous keratin expression epidermal keratins hair keratins

From the encyclopedia

Keratin →

retinoic acid →

Vitamin D →

vitamin you should probably be taking for general health might also help your hair a little

Studysummary This review discusses the complex hormonal control of keratin expression in skin and its potential implications for treating skin and hair disorders, but reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The review article discussed the critical role of endocrine controls in the expression of keratins, which are essential intermediate filaments in skin physiology. It highlighted that keratin gene and protein expression in mammalian skin are tightly regulated by various hormones, including thyroid hormones, glucocorticoids, retinoic acid, vitamin D, and neuroendocrine mediators. Understanding these endocrine controls is crucial for gaining insights into normal skin and hair function and could lead to new therapeutic approaches for various skin and hair diseases.

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Research cited in this study

33 / 33 results

research Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone

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research Identification of Novel Glucocorticoid Receptor-Regulated Genes Involved in Epidermal Homeostasis and Hair Follicle Differentiation

19 citations , September 2007 in “The Journal of Steroid Biochemistry and Molecular Biology”

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Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

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128 citations , March 2006 in “American Journal of Pathology”

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56 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

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146 citations , January 2004 in “Hormones”

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research De Novo Mutations in Monilethrix

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235 citations , July 1999 in “Journal of biological chemistry/The Journal of biological chemistry”

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research Keratin 17 Gene Expression During the Murine Hair Cycle

70 citations , March 1997 in “Journal of Investigative Dermatology”

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