Human Hair Keratin-Associated Proteins

    August 2005 in “ ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings ”
    Yutaka Shimomura, Masaaki Ito
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    TLDR Hair keratin-associated proteins are essential for strong hair, with over 80 genes showing specific patterns and variations among people.
    Hair keratin-associated proteins (KAP) were identified as crucial components of the hair fiber, forming a strong hair shaft by cross-linking with keratin intermediate filaments. Advances in the study of human KAP led to the characterization of five gene clusters and the identification of over 80 individual KAP genes. In situ hybridization revealed specific expression patterns of KAP genes in different parts of the hair fiber. Additionally, several KAP genes exhibited size polymorphisms due to variable cysteine-rich repeat segments, with distinct patterns observed among different human populations.
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