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    Glossary Keratin Intermediate Filaments

    structural proteins in cells providing support and resilience

    Keratin Intermediate Filaments (KIFs) are structural proteins found in epithelial cells, including those in the skin, hair, and nails. They provide mechanical support and resilience, helping cells withstand stress and maintain their shape. KIFs are a type of intermediate filament, which are part of the cytoskeleton, a network that supports cell structure and function.

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    1. ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments Current Opinion in Cell Biology · 2002 · 686 citations
    2. The expanding significance of keratin intermediate filaments in normal and diseased epithelia Current opinion in cell biology · 2012 · 186 citations
    3. Expression patterns of keratin intermediate filament and keratin associated protein genes in wool follicles Differentiation · 2009 · 95 citations
    4. Cryo-Electron Microscopy of Trichocyte (Hard α-Keratin) Intermediate Filaments Reveals a Low-Density Core Journal of Structural Biology · 2002 · 48 citations
    5. Keratin intermediate filaments in the colon: guardians of epithelial homeostasis International journal of biochemistry & cell biology · 2020 · 38 citations
    6. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament Genomics · 2007 · 27 citations
    7. Structural changes in trichocyte keratin intermediate filaments during keratinization Journal of Structural Biology · 2003 · 23 citations
    8. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
    9. Structural Hierarchy of Trichocyte Keratin Intermediate Filaments Advances in experimental medicine and biology · 2018 · 15 citations
    10. Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair Journal of The Royal Society Interface · 2017 · 8 citations
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