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    Glossary Keratin Intermediate Filaments

    structural proteins in cells providing support and resilience

    Keratin Intermediate Filaments (KIFs) are structural proteins found in epithelial cells, including those in the skin, hair, and nails. They provide mechanical support and resilience, helping cells withstand stress and maintain their shape. KIFs are a type of intermediate filament, which are part of the cytoskeleton, a network that supports cell structure and function.

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    1. ‘Hard’ and ‘soft’ principles defining the structure, function and regulation of keratin intermediate filaments Current Opinion in Cell Biology · 2002 · 686 citations
    2. The expanding significance of keratin intermediate filaments in normal and diseased epithelia Current opinion in cell biology · 2012 · 186 citations
    3. Expression patterns of keratin intermediate filament and keratin associated protein genes in wool follicles Differentiation · 2009 · 95 citations
    4. Cryo-Electron Microscopy of Trichocyte (Hard α-Keratin) Intermediate Filaments Reveals a Low-Density Core Journal of Structural Biology · 2002 · 48 citations
    5. Keratin intermediate filaments in the colon: guardians of epithelial homeostasis International journal of biochemistry & cell biology · 2020 · 38 citations
    6. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament Genomics · 2007 · 27 citations
    7. Structural changes in trichocyte keratin intermediate filaments during keratinization Journal of Structural Biology · 2003 · 23 citations
    8. Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation Journal of Structural Biology · 2006 · 19 citations
    9. Structural Hierarchy of Trichocyte Keratin Intermediate Filaments Advances in experimental medicine and biology · 2018 · 15 citations
    10. Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair Journal of The Royal Society Interface · 2017 · 8 citations
    11. pH Dependence of the Coiled-Coil Structure of Keratin Intermediate Filament in Human Hair by 13C NMR Spectroscopy and the Mechanism of Its Disruption Polymer journal · 1998 · 7 citations
    12. Supplementary material from "Giant axonal neuropathy alters the structure of keratin intermediate filaments in human hair" 2017
    13. Annotation of sheep keratin intermediate filament genes and their patterns of expression Experimental Dermatology · 2011 · 83 citations
    14. Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998 · 46 citations
    15. The Intermediate Filament Architecture as Determined by X-Ray Diffraction Modeling of Hard α-Keratin Biophysical Journal · 2004 · 66 citations
    16. Types I and II Keratin Intermediate Filaments Cold Spring Harbor Perspectives in Biology · 2018 · 211 citations
    17. In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments 2000 · 91 citations
    18. In vivo formation steps of the hard α-keratin intermediate filament along a hair follicle: Evidence for structural polymorphism Journal of Structural Biology · 2006 · 22 citations
    19. Three-dimensional modelling of interchain sequence similarities and differences in the coiled-coil segments of keratin intermediate filament heterodimers highlight features important in assembly Journal of Structural Biology · 2007 · 13 citations
    20. Self-consistent field theory for the interactions between keratin intermediate filaments BMC Biophysics · 2013 · 12 citations
    21. Regulation of hard α-keratin mechanics via control of intermediate filament hydration: matrix squeeze revisited Proceedings of the Royal Society B Biological Sciences · 2012 · 30 citations
    22. Regulation of a hair follicle keratin intermediate filament gene promoter Journal of Cell Science · 1998 · 39 citations
    23. Carbon-13 n.m.r. studies of keratin intermediate filament of human hair Polymer · 1998 · 5 citations
    24. Complete sequence of a hair-like intermediate filament type II keratin gene DNA sequence · 1993 · 15 citations
    25. The Molecular Architecture for the Intermediate Filaments of Hard<i>α</i>-Keratin Based on the Superlattice Data Obtained from a Study of Mammals Using Synchrotron Fibre Diffraction Biochemistry Research International · 2011 · 7 citations
    26. Direct evidence supporting the existence of a helical dislocation in protofilament packing in the intermediate filaments of oxidized trichocyte keratin Journal of Structural Biology · 2018 · 3 citations
    27. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n (K17n), Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004 · 31 citations
    28. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    29. Apoptosis and keratin intermediate filaments Cell Death and Differentiation · 2002 · 180 citations
    30. Structure and Mechanical Properties of Human Trichocyte Keratin Intermediate Filament Protein Biomacromolecules · 2012 · 51 citations