Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

    September 2019 in “ Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic ”
    Jiaxiao Shi, Peng Peng, Weixiao Liu, Peng Mi, Cong Xing, Guangzhi Ning, Shiqing Feng
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    TLDR CD2 might be a new treatment target for patchy alopecia areata.
    The study analyzed gene expression profiles from 22 patients with patchy-type alopecia areata (AAP) and 36 normal controls, identifying 185 differentially expressed genes (DEGs), with 45 up-regulated and 140 down-regulated. Up-regulated genes were linked to immune response and chemokine signaling, while down-regulated genes were associated with keratin and intermediate filaments. The protein-protein interaction network highlighted CD2 as a key hub gene, suggesting it could be a new therapeutic target for AAP. Further research was recommended to explore CD2's potential in treating alopecia areata.
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