Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing

August 2015 in “ The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology ”

Mayte Suárez‐Fariñas, Benjamin Ungar, Shinichi Noda, Anjali Shroff, Yasaman Mansouri, Judilyn Fuentes‐Duculan, Annette Czernik, Xiuzhong Zheng, Yeriel Estrada, Hui Xu, Xiangyu Peng, Avner Shemer, James G. Krueger, Mark Lebwohl, Emma Guttman‐Yassky

alopecia areata TH1 TH2 IL-23 IL-9 TH9 cytokine activation immune activation hair keratin genes atopic dermatitis psoriasis AA AD

Studysummary This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.

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