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GlossaryT-helper 2 cell (Th2)

immune cell involved in allergic reactions and parasite defense

A T-helper 2 (Th2) cell is a type of immune cell that plays a crucial role in the body's defense against extracellular parasites, such as helminths, and is also involved in allergic reactions. Th2 cells produce cytokines like IL-4, IL-5, and IL-13, which help stimulate the production of antibodies by B cells and promote the activation of other immune cells.

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An Integrated Model of Alopecia Areata Biomarkers Highlights Both Th1/Th2 Upregulation, with Stronger Correlations Between Th2 Activation and Disease Severity

research An Integrated Model of Alopecia Areata Biomarkers Highlights Both Th1/Th2 Upregulation, with Stronger Correlations Between Th2 Activation and Disease Severity

April 2018 in “Journal of Investigative Dermatology”

Both Th1 and Th2 immune responses are increased in alopecia areata, with Th2 response more strongly linked to how severe the disease is.

research Frontal Fibrosing Alopecia Scalp Profiling Links Th1/Th2 And JAK3 Activation With Fibrosis And Loss Of Follicular Stem Cells

April 2019 in “Journal of Investigative Dermatology”

Targeting immune pathways like JAK/STAT may help treat frontal fibrosing alopecia.

research Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

2 citations , April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals

18 citations , May 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different parts of the body have unique immune characteristics in their skin.

research Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment

65 citations , December 2015 in “Experimental dermatology”

Corticosteroid treatment reduces inflammation and alters hair keratins in alopecia areata.

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community Fin/dut increase in estrogen and autoimmune diseases

in Chat 7 upvotes 2 years ago

The conversation discusses the link between increased estrogen and autoimmune diseases, with a focus on avoiding soy and milk. It also mentions treatments like Minoxidil, finasteride, and RU58841 for hair loss.

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

in Treatment 64 upvotes 6 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community 8 years of hair loss, turning 30 next month

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The user has been dealing with hair loss for 10 years, worsened by psoriasis, and uses minoxidil and finasteride. They seek advice on managing psoriasis and hair loss, with suggestions to see a dermatologist, try different shampoos, and be patient.

community When someone posts a scalp tension theory

in Satire 264 upvotes 4 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.