An Integrated Model of Alopecia Areata Biomarkers Highlights Both TH1 and TH2 Upregulation

    July 2018 in “ Journal of Allergy and Clinical Immunology ”
    Teresa Song, Ana B. Pavel, Huei‐Chi Wen, Kunal Malik, Yeriel Estrada, Juana Gonzalez, Peter W. Hashim, John K Nia, Danielle Baum, Grace W. Kimmel, Giselle Singer, James G. Krueger, Emma Guttman‐Yassky
    TLDR Alopecia areata severity is linked to increased TH1 and TH2 activity.
    The study on alopecia areata (AA) involved 30 patients with moderate-to-severe AA and 10 controls, focusing on TH1 and TH2 pathway upregulation. It found increased levels of TH1/IFN-γ and TH2 markers in AA patients, with serum IL-15 and eotaxin/CCL11 levels linked to clinical severity. The research suggested serum biomarkers like IL-15 and CCL13 could reflect AA severity and be used in therapeutic trials. Greater TH2 activation was associated with increasing severity, and TH1 skewing with longer disease duration. The study emphasized the need for further research on cytokine profiles and acknowledged limitations such as a small sample size and focus on adults with high disease severity.
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