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GlossaryT helper 1 cell (Th1)

immune cells that activate macrophages to fight intracellular pathogens

T helper 1 cells, often abbreviated as Th1 cells, are a type of immune cell that play a crucial role in the body's defense against intracellular pathogens like viruses and certain bacteria. They produce cytokines, such as interferon-gamma (IFN-γ), which activate macrophages and enhance the ability of other immune cells to destroy infected cells.

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Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

278 citations, March 2013 in “Gut”

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

research Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing

176 citations, August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations, December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

18 citations, January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Th1/Th2 Peripheral Blood Balance and CD200 Expression in Patients with Active Severe Alopecia Areata

12 citations, April 2017 in “Experimental and Therapeutic Medicine”

Patients with severe active alopecia areata have lower CD200 expression and an imbalance in their immune system.

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community I’ve emailed MinoxidilMax and they’ve said they will try and make topical Procyanidin B2 within a month!

in Product 94 upvotes 3 years ago

User TH1RT33N_DR34M shares that MinoxidilMax plans to make topical Procyanidin B2 within a month. Users discuss the legitimacy of the product, quality control, and potential results from using it for hair loss.

community Melatonin a possible tool to help fight AGA hair loss.

in Research/Science 52 upvotes 4 years ago

Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.

community 6 month hairline results (dutasteride and microneedling)

in Progress Pictures 802 upvotes 4 years ago

A user's 6 month hairline results from using dutasteride and microneedling, which resulted in successful regrowth of their thinning temples. Other users commented with similar experiences that were also achieved through the use of finasteride, dutasteride and minoxidil.

community 5 Months – Topical Fin (0.3%), Min (6%), Microneedle Weekly 1.5mm, 40 y/o

in Progress Pictures 108 upvotes 2 years ago

A user's progress with hair loss treatments over 5 months, using topical finasteride (0.3%) and minoxidil (6%), as well as weekly microneedling sessions; other users have asked questions about the results and offered compliments.

community New company bringing Minoxidil + Finasteride + Bimatoprost topical to market

in Treatment 49 upvotes 5 years ago

A new company is introducing a topical treatment combining Minoxidil, Finasteride, and Bimatoprost for hair loss. Users are also inquiring about updates on a minoxidil-enhancing shampoo from Applied Biology.

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