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GlossaryT helper 17 cells (Th17)

specialized immune cells involved in inflammation and autoimmune responses

T helper 17 cells, often abbreviated as Th17 cells, are a subset of T cells, which are a type of white blood cell crucial for the immune system. Th17 cells play a key role in defending the body against bacterial and fungal infections by producing a specific set of signaling molecules called cytokines, particularly interleukin-17 (IL-17). They are also involved in inflammatory responses and have been implicated in various autoimmune diseases, where the immune system mistakenly attacks the body's own tissues.

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research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations , December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Molecular Profiling of Frontal Fibrosing Alopecia Reveals TH1 and JAK-STAT Up-Regulation with No Suppression of Hair Keratins

2 citations , April 2018 in “Journal of Investigative Dermatology”

Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.

research Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

5 citations , February 2022 in “Seminars in cell & developmental biology”

Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.

research Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals

18 citations , May 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different parts of the body have unique immune characteristics in their skin.

research Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata

62 citations , June 2015 in “The Journal of Dermatology”

People with alopecia areata have more Th17 cells and fewer Treg cells, which may be key to the condition's development.

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