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GlossaryT helper 17 cells (Th17)

specialized immune cells involved in inflammation and autoimmune responses

T helper 17 cells, often abbreviated as Th17 cells, are a subset of T cells, which are a type of white blood cell crucial for the immune system. Th17 cells play a key role in defending the body against bacterial and fungal infections by producing a specific set of signaling molecules called cytokines, particularly interleukin-17 (IL-17). They are also involved in inflammatory responses and have been implicated in various autoimmune diseases, where the immune system mistakenly attacks the body's own tissues.

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Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

research Anti-TNF Antibody-Induced Psoriasiform Skin Lesions in Patients with Inflammatory Bowel Disease Are Characterised by Interferon-γ-Expressing Th1 Cells and IL-17A/IL-22-Expressing Th17 Cells and Respond to Anti-IL-12/IL-23 Antibody Treatment

278 citations , March 2013 in “Gut”

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

18 citations , January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

research Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells

4 citations , January 2011 in “Journal of UOEH”

Autoimmune hair loss may be linked to increased Th1 and Th17 cells and decreased Th2 cells.

research Inheritance-Specific Dysregulation of Th1 and Th17-Associated Cytokines in Alopecia Areata

1 citations , August 2023 in “Biomolecules”

Certain immune-related proteins are higher in people with alopecia and their healthy relatives, hinting at a genetic link.

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