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GlossaryTh17 Cytokines

signaling proteins from T helper 17 cells that promote inflammation

Th17 cytokines are signaling proteins produced by a specific subset of immune cells known as T helper 17 (Th17) cells. These cytokines play a crucial role in the body's defense against bacterial and fungal infections, as well as in the development of inflammatory and autoimmune diseases. They help coordinate the immune response by promoting inflammation, which can be beneficial in fighting infections but may also contribute to conditions like psoriasis and rheumatoid arthritis.

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research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations, December 2021 in “Cells”

Alopecia areata severity and treatment response are linked to specific cytokine levels.

research Decreased IL-10 Producing Regulatory B Cells in Patients With Alopecia Areata

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

People with alopecia areata have fewer IL-10 producing immune cells, which might contribute to the condition.

Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

research Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

June 2022 in “Frontiers in Immunology”

Tofacitinib regrew hair in a man with total hair loss but raised cytokine levels, needing more research on possible side effects.

research Inheritance-Specific Dysregulation of Th1 and Th17-Associated Cytokines in Alopecia Areata

1 citations, August 2023 in “Biomolecules”

Certain immune-related proteins are higher in people with alopecia and their healthy relatives, hinting at a genetic link.

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations, November 2020 in “Frontiers in immunology”

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

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