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    Glossary Th17 Cytokines

    signaling proteins from T helper 17 cells that promote inflammation

    Th17 cytokines are signaling proteins produced by a specific subset of immune cells known as T helper 17 (Th17) cells. These cytokines play a crucial role in the body's defense against bacterial and fungal infections, as well as in the development of inflammatory and autoimmune diseases. They help coordinate the immune response by promoting inflammation, which can be beneficial in fighting infections but may also contribute to conditions like psoriasis and rheumatoid arthritis.

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    1. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021 · 37 citations
    2. Inheritance-Specific Dysregulation of Th1- and Th17-Associated Cytokines in Alopecia Areata Biomolecules · 2023 · 1 citations
    3. A new TH17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26 2020
    4. Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing 2015 · 176 citations
    5. Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal? Frontiers in Immunology · 2022
    6. Decreased CD200R expression on monocyte-derived macrophages correlates with Th17/Treg imbalance and disease activity in rheumatoid arthritis patients Inflammation Research · 2014 · 31 citations
    7. Healthy individuals genetically at-risk for the development of Pemphigus vulgaris or Alopecia areata share disease-like cytokine dysregulation Frontiers in Immunology · 2025 · 1 citations
    8. Olink proteomics analysis of scalp psoriasis reveals a cytokine storm inflammatory mainly related to bacterial-derived antigens 2025
    9. Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases 2017 · 25 citations
    10. The effect of 5-α reductase inhibitor on Th1, Th2, and Th17 cell-related inflammatory response in BPH World Journal of Urology · 2023 · 1 citations
    11. Detection of subtypes of T helper cells and their cytokines in peripheral blood of patients with systematic lupus erythematosus and their clinical significances Journal of Jilin University · 2014
    12. Alopecia Areata: A Complex Cytokine Driven Disease 2020 · 3 citations
    13. Hair follicles as immune targets: unraveling cellular players, cytokine crosstalk, and precision pathways for future therapy of alopecia areata Expert Review of Clinical Immunology · 2026
    14. From mechanisms to therapies: current advances breakthroughs in alopecia areata immunopathology Frontiers in Immunology · 2025 · 3 citations
    15. Optimisation of a Murine Infection Model With <i>Trichophyton mentagrophytes</i> for Studying the Pathogenesis of Dermatophytosis Mycoses · 2025
    16. 148 Decreased IL-10 producing regulatory B cells in patients with alopecia areata 2023
    17. CD169+ Skin Macrophages Function as a Specialized Subpopulation in Promoting Psoriasis-like Skin Disease in Mice International Journal of Molecular Sciences · 2024 · 2 citations
    18. SnapshotDx Quiz: September 2016 Journal of Investigative Dermatology · 2016
    19. Overlapping features of atopic dermatitis and alopecia areata: from pathogenesis to treatment Frontiers in Immunology · 2025
    20. Cutaneous Manifestations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED): A Comprehensive Review Biomedicines · 2024
    21. The role of lymphocytes in the development and treatment of alopecia areata Expert Review of Clinical Immunology · 2015 · 60 citations
    22. Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata BBA clinical · 2016 · 12 citations
    23. The immunopathogenesis of Alopecia Areata Enlighten: Theses (The University of Glasgow) · 2020 · 2 citations
    24. Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes International Journal of Molecular Sciences · 2024
    25. Severe pustular lesions induced by topical immunotherapy with squaric acid dibutylester for alopecia totalis Journal of Cutaneous Immunology and Allergy · 2019 · 1 citations
    26. Markers of inflammation, metabolic disorders, and principles of treatment for alopecia areata in children Voprosy praktičeskoj pediatrii · 2025
    27. 545 Skin Organoids derived from NCSTN mutated patient-induced pluripotent stem cells recapitulate Hidradenitis Suppurativa pathogenic hallmarks 2022
    28. The role of leptin in selected skin diseases Lipids in Health and Disease · 2020 · 16 citations
    29. Gingerol ameliorates chronic graft-versus-host disease by regulating treg/Th17 transdifferenciation Blood · 2025
    30. 1318 Both lesional and non-lesional skin from acne patients shows robust IL-17-skewing and upregulation of antimicrobial peptides Journal of Investigative Dermatology · 2018