T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities

    March 2018 in “ British journal of dermatology/British journal of dermatology, Supplement ”
    Bodo C. Melnik, Swen Malte John, W. Chen, Gerd Plewig
    Studysummary This article reviews the role of perifollicular regulatory T cells in maintaining hair follicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.
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    Research cited in this study 8

    1. Hidradenitis Suppurativa in Children Treated with Finasteride: A Case Series Pediatric Dermatology · 2017
    2. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    3. Hidradenitis Suppurativa/Acne Inversa: An Endocrine Skin Disorder? Reviews in endocrine and metabolic disorders · 2016
    4. A Case Series of 20 Women with Hidradenitis Suppurativa Treated with Spironolactone Australasian Journal of Dermatology · 2015
    5. Deciphering the Functions of the Hair Follicle Infundibulum in Skin Physiology and Disease Cell and Tissue Research · 2014
    6. Impaired Notch-MKP-1 Signalling in Hidradenitis Suppurativa: An Approach to Pathogenesis by Evidence from Translational Biology Experimental dermatology · 2013
    7. Diseases Associated With Hidradenitis Suppurativa: Part 2 of a Series on Hidradenitis Dermatology Online Journal · 2013
    8. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011