TLDR An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.
The document from June 11, 2018, discusses the connection between T helper 17 (Th17) cells and regulatory T cells (Tregs) in the context of hidradenitis suppurativa (HS)/acne inversa, a chronic skin condition characterized by the dissection of terminal hair follicles. It highlights that patients with HS/acne inversa exhibit elevated levels of interleukin-17 (IL-17) in their serum and an increased ratio of proinflammatory Th17 cells to anti-inflammatory Tregs in affected skin areas. This imbalance is suggested to play a role in the disintegration of hair follicle infundibula, which is a key histological feature of the disease. Additionally, the document indicates that Tregs are crucial for maintaining hair follicle stem cell homeostasis and infundibular integrity, suggesting that their dysregulation may contribute to the pathogenesis of HS/acne inversa. The document also notes that HS/acne inversa is associated with obesity, smoking, and autoimmune comorbidities, which may be linked to the Th17/Treg imbalance.
19 citations,
July 2017 in “Pediatric Dermatology” Finasteride improves hidradenitis suppurativa in children with no adverse effects.
44 citations,
July 2016 in “Stem Cells Translational Medicine” Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.
41 citations,
June 2016 in “Reviews in endocrine and metabolic disorders” Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.
54 citations,
June 2015 in “Australasian Journal of Dermatology” Spironolactone is an effective and well-tolerated first-line treatment for hidradenitis suppurativa in women.
38 citations,
September 2014 in “Cell and Tissue Research” The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.
112 citations,
January 2013 in “Experimental dermatology” Faulty Notch signalling may cause hair follicle changes and inflammation in hidradenitis suppurativa.
61 citations,
January 2011 in “PloS one” Notch signaling is essential for healthy skin and hair follicle maintenance.
4 citations,
October 2022 in “Genes” Our microbiome may affect the development of the hair loss condition Alopecia Areata, but more research is needed to understand this relationship.
16 citations,
September 2020 in “British journal of dermatology/British journal of dermatology, Supplement” The article suggests that targeting specific immune pathways could help control and treat the skin disease hidradenitis suppurativa.
4 citations,
March 2009 in “British Journal of Dermatology” The conference highlighted new dermatological treatments and emphasized early intervention and addressing conditions lacking evidence-based treatments.
16 citations,
January 2022 in “International journal of molecular sciences” Certain daily habits like stress, diet, and sleep can affect the severity of hair loss in alopecia areata.
May 2023 in “Journal of Clinical Medicine” New understanding and treatments for hair loss are improving, but more research is needed.
