Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors

    July 2016 in “ Stem Cells Translational Medicine ”
    Xiaoxiao Wang, Xusheng Wang, Jianjun Li … Yaojiong Wu
    Studysummary This study demonstrated that cultured epidermal stem cells and skin-derived precursors can regenerate functional hair follicles and sebaceous glands in both mice and adult humans, suggesting potential for bioengineered skin substitutes.
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    Research cited in this study 18

    1. Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands Molecular and Cellular Biology · 2014
    2. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    3. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    4. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    5. Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach Journal of Investigative Dermatology · 2013
    6. Development and Homeostasis of the Sebaceous Gland Seminars in Cell & Developmental Biology · 2012
    7. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011
    8. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    9. SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells Cell stem cell · 2009
    10. Hair Follicle Neogenesis Induced by Cultured Human Scalp Dermal Papilla Cells Regenerative Medicine · 2009
    11. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    12. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    13. Behavior of Human Foreskin Keratinocytes Expressing a Hair Follicle Stem Cell Marker CD200 Journal of Investigative Dermatology · 2007
    14. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    15. Scratching the Surface of Skin Development Nature · 2007
    16. Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    17. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    18. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000

    Related research 8

    1. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022
    2. Epidermal Stem Cells in Wound Healing and Regeneration Stem Cells International · 2020
    3. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    4. Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors Stem Cells Translational Medicine · 2016
    5. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    6. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014
    7. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    8. Stem Cells in Embryonic Skin Development Biological Research · 2012