Hair Follicle and Sebaceous Gland De Novo Regeneration With Cultured Epidermal Stem Cells and Skin-Derived Precursors

July 2016 in “ Stem Cells Translational Medicine ”

Xiaoxiao Wang, Xusheng Wang, Jianjun Li, Ting Cai, Ling Guo, Shujuan Wang, Jinmei Wang, Yanpei Cao, Jianfeng Ge, Yuyang Jiang, Edward E. Tredget, Mengjun Cao, Yaojiong Wu

Epidermal Stem Cells Skin-Derived Precursors hair follicles Sebaceous Glands induction cocktail sebocytes bioengineered skin substitutes epidermal appendages Epi-SCs SKPs SGs

TLDR Scientists discovered that certain stem cells from mice and humans can be used to grow new hair follicles and skin glands when treated with a special mixture.

In 2016, researchers found that a combination of cultured Epidermal Stem Cells (Epi-SCs) and Skin-Derived Precursors (SKPs) from mice and adult humans could regenerate hair follicles and functional Sebaceous Glands (SGs). The Epi-SCs, when treated with a specific induction cocktail, differentiated into sebocytes and formed SGs. When implanted with SKPs, they formed SGs in association with hair follicles. The presence of the induction cocktail in the graft significantly increased the number of SGs formed. The newly formed SGs were functional, secreting lipids similar to normal skin and protecting against water evaporation. The study suggested potential applications in treating hair loss conditions and the development of bioengineered skin substitutes capable of regenerating epidermal appendages.

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