Dynamic Signals for Hair Follicle Development and Regeneration

    July 2011 in “ Stem Cells and Development ”
    Xusheng Wang, Edward E. Tredget, Yaojiong Wu
    Image of study
    TLDR Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.
    The 2011 review "Dynamic Signals for Hair Follicle Development and Regeneration" discussed the molecular signals involved in hair follicle development and regeneration. Key signaling pathways and regulatory genes were identified using genetically engineered mouse models, including Wnt/ß-catenin signaling, ectodysplasin (Eda)-A1/nuclear factor kappa-B (NF-KB) pathway, bone morphogenetic protein (BMP), Sonic Hedgehog (Shh), Dickkopf-1/4 (Dkk-1/4), noggin, and adenomatosis polyposis coli downregulated 1 (APCDD1). The study also highlighted the role of stem cells in hair follicle development and regeneration, particularly cutaneous stem cells located in the bulge region of the hair follicle. The absence of hair follicle regeneration in healing wounds was attributed to a lack of proper inductive signals, not due to malfunction of these stem cells. The study concluded that a better understanding of these signals could lead to novel molecular therapies for cutaneous regeneration.
    Discuss this study in the Community →

    Research cited in this study

    45 / 45 results

    Related Community Posts Join

    6 / 120 results

      community Opinions on this study for Triphasic Progressive by Rene Furterer

      in Research/Science  14 upvotes 2 years ago
      The user shared their 5-year hair loss journey, initially using a product called Triphasic Progressive by Rene Furterer, which gave good results. Later, they switched to FDA-approved medications finasteride and minoxidil, which also helped, but they noticed the most significant progress with Triphasic. They're considering trying it again if minoxidil doesn't show improvements.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  6 upvotes 3 years ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.

    Related Research

    4 / 4 results