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GlossaryAPC Down-Regulated 1 (APCDD1)

gene involved in hair growth and development

APC Down-Regulated 1 (APCDD1) is a gene that plays a role in hair growth and development. Mutations in this gene have been linked to hereditary hypotrichosis simplex, a condition characterized by progressive hair loss starting in childhood. This gene is involved in the Wnt signaling pathway, which is crucial for the regulation of hair follicle development and cycling.

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research APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex

199 citations, April 2010 in “Nature”

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

research A Synonymous Polymorphism of APCDD1 Affects Translation Efficacy and Is Associated with Androgenic Alopecia

January 2014 in “生命科学（ISSN1934-7391）”

A certain gene variation can affect protein production and is linked to male pattern baldness.

research A Synonymous Polymorphism of APCDD1 Affects Translation Efficacy and Is Associated with Androgenic Alopecia

January 2014

A specific gene change in APCDD1 increases the risk of hair loss.

research Biology and Genetics of Hair

89 citations, September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research Dynamic Signals for Hair Follicle Development and Regeneration

60 citations, July 2011 in “Stem Cells and Development”

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

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