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GlossaryAPC Down-Regulated 1 (APCDD1)

gene involved in hair growth and development

APC Down-Regulated 1 (APCDD1) is a gene that plays a role in hair growth and development. Mutations in this gene have been linked to hereditary hypotrichosis simplex, a condition characterized by progressive hair loss starting in childhood. This gene is involved in the Wnt signaling pathway, which is crucial for the regulation of hair follicle development and cycling.

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research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research News in Brief

June 2010 in “Expert Review of Dermatology”

Scientists found key proteins and genes that affect skin and hair health, and identified potential new treatments for hair loss, skin disorders, and wound healing.

research APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex

199 citations , April 2010 in “Nature”

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

research Genetics of Structural Hair Disorders

17 citations , November 2012 in “Journal of Investigative Dermatology”

The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.

research A Synonymous Polymorphism of APCDD1 Affects Translation Efficacy and Is Associated with Androgenic Alopecia

January 2014

A specific gene change in APCDD1 increases the risk of hair loss.

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