Tretinoin vs. micro-needling: what increases sulfotransferase activity more? Research/Science 7/3/2025
Tretinoin and microneedling both enhance hair growth through different mechanisms, with microneedling being considered safe for long-term use. Optimal microneedling needle length varies, but 0.8 mm is suggested for hair growth, and a Dermastamp is recommended to avoid skin damage.
View this post in the Community →
Similar Community Posts Join
5 / 5 resultscommunity Microneedling, some people seem to permanently lost their hair. Confused
Microneedling can aid hair regrowth but poses risks like permanent hair loss if not done properly. Combining it with minoxidil, finasteride, and tretinoin, while ensuring proper sterilization and technique, is crucial for safety and effectiveness.
community Comprehensive Microneedling Guide
Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.
community M25: Getting way too many DMs, so let’s do this here! AMA about Male Pattern Baldness, Hair Loss, and Products (100% Science-Backed )
Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.
community No sign of improvement after one year on Fin 1mg daily
Finasteride is used to prevent further hair loss, not for regrowth. Adding minoxidil is suggested for potential hair regrowth.
community Minoxidil + Tretinoin if you suspect you have low sulfotransferase enzyme activity
Minoxidil may not be effective due to low sulfotransferase activity, and the user considers adding tretinoin to the regimen. They are unsure about the timing and combination with microneedling.
Related Research
6 / 6 results
research Facial hair enhancement with minoxidil—an off-label use
This report describes the case of identical twin males, where one applied topical 5% minoxidil for over a year on the beard and mustache area and the other did not, highlighting the anecdotal use of minoxidil for facial hair enhancement.
research Sulfotransferase SULT1A1 activity in hair follicle, a prognostic marker of response to the minoxidil treatment in patients with androgenetic alopecia: a review
This review discusses the potential of using SULT1A1 expression in the scalp as a biomarker to predict response to minoxidil treatment for androgenetic alopecia, but reports no new clinical results.
research Microneedling improves minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes.
research A review of the treatment of male pattern hair loss
This review discusses pharmacologic and non-pharmacologic treatments for androgenetic alopecia, noting that current medications like finasteride and minoxidil can slow hair loss but only partially restore hair growth, with early treatment offering better outcomes.
research Female pattern hair loss: A clinical, pathophysiologic, and therapeutic review
This article discusses treatments for female pattern hair loss, highlighting that oral antiandrogens and topical minoxidil can effectively arrest progression and reverse miniaturization in many patients with mild-to-moderate cases, but it reports no new clinical results.
research The diagnosis and treatment of androgenetic alopecia: a review of the most current management
This source discusses androgenetic alopecia, noting that male patients may transition from topical minoxidil to its systemic form or from finasteride to dutasteride for potentially better results, while female patients might require extensive lab testing to identify hyperandrogenism due to environmental triggers.