Minoxidil + Tretinoin if you suspect you have low sulfotransferase enzyme activity
    Minoxidil 4/12/2025

    From the encyclopedia
    Minoxidil →

    Vasodilator used on the scalp and, at low doses, as a tablet

    Tretinoin →

    Vitamin A retinoid cream, prescribed for acne

    Microneedling →

    Technique that makes tiny punctures in the scalp with fine needles

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💧 Minoxidil (topical) foam 4 months
    💧 Tretinoin (topical)
    the tone is 😐 neutral.

    Other terms

    Minoxidil may not be effective due to low sulfotransferase activity, and the user considers adding tretinoin to the regimen. They are unsure about the timing and combination with microneedling.
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      community Who won’t respond to minoxidil? (Studies)

       33 upvotes 6 months ago
      Minoxidil's effectiveness varies due to differences in sulfotransferase enzyme levels in the scalp, affecting people with conditions like ASD, liver disease, and androgenic alopecia. Treatments like topical tretinoin, microneedling, and using minoxidil sulfate instead of regular minoxidil can improve results for those with low enzyme levels.

      community Any long term positive experiences with just minoxidil plus a dermaroller?

      in Minoxidil  10 upvotes 8 months ago
      Minoxidil and dermarolling can yield positive hair growth results, but long-term effectiveness varies, and some users experience hair loss again without additional treatments like finasteride. Microneedling enhances minoxidil's effectiveness by increasing enzyme activity, but individual experiences differ.

      community Starting out - Minoxidil Questions

      in Minoxidil  4 upvotes 3 years ago
      A 38-year-old man with male pattern baldness is considering using topical Minoxidil and possibly Finasteride but is concerned about Finasteride's side effects on fertility. He plans to try different application methods for Minoxidil and is advised that while Minoxidil may not work for everyone, it is less likely to have side effects compared to oral treatments.

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    6 / 6 results