Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

    Camila O. Cardoso, Seila Tolentino, Taís Gratieri, Marcílio Cunha-Filho, Renata Fonseca Vianna Lopez
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    TLDR Minoxidil and finasteride are the best for non-scarring hair loss; more research is needed for scarring hair loss treatments.
    The document "Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence" reviews the effectiveness of various topical treatments for alopecia. Minoxidil and finasteride are the most effective treatments for non-scarring alopecia, with minoxidil increasing hair growth by 40% in 3-6 months. For scarring alopecia, topical corticosteroids and calcineurin inhibitors show promise, but more research is needed. The paper also discusses the use of nanoparticles in topical treatments, which can reduce irritant potential, control drug release, and increase drug penetration. Techniques like iontophoresis, sonophoresis, and microneedling are also mentioned as potential strategies for enhancing drug delivery. The document concludes by emphasizing the need for more clinical studies to determine the effectiveness and safety of these new therapeutic modalities for the treatment of hair loss.
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      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 2 months ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

      community Hair came back in 3 months at 39y/o.

      in Progress Pictures  421 upvotes 1 year ago
      A user shared their successful hair regrowth using a combination of minoxidil, caffeine, biotin, and RU58841, along with weekly dermarolling. However, others advised against the user's plan to switch to rosemary oil and microneedling only, emphasizing the importance of continuing the current treatment to maintain the results.

      community 14 months into fin + min and my hair is way worse than before

      in Chat  22 upvotes 4 months ago
      The user experienced worsening hair loss despite using finasteride, minoxidil, and microneedling. Suggestions included reducing microneedling frequency, switching to oral minoxidil, adding tretinoin, and considering dutasteride.
      Shedding or receding even more?

      community Shedding or receding even more?

      in Journals / Progress Pictures  139 upvotes 2 days ago
      The user experienced hair shedding after using finasteride and topical minoxidil since August 2024, and briefly adding oral minoxidil in early 2025. They suspect the shedding might be due to the oral minoxidil, a bad batch of finasteride, or a normal shedding cycle, and are also experiencing an itchy scalp and acne.

      community One year of progress (Fin, 1mg)

      in Is this regrowth?  281 upvotes 1 month ago
      The user started finasteride (1mg) a year ago for hair thinning, experiencing stabilization but not significant regrowth. Suggestions included adding minoxidil, microneedling, and considering a hair transplant for improved results.

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