Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

    April 2009 in “ International Journal of Pharmaceutics ”
    Prabagar Balakrishnan, Srinivasan Shanmugam, Won Young Lee, Won-Mo Lee, Jong Min Kim, Dong Joo Oh, Dae-Duk Kim, Jung Hyun Kim, Bong Kyu Yoo, Han-Gon Choi, Jong Inn Woo, Chul Soon Yong
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    TLDR Niosomes improve minoxidil skin delivery for hair loss treatment.
    This study explores the use of niosomes, a type of vesicular carrier, to improve the skin delivery of minoxidil, a drug used to treat hair loss. The niosomes were prepared using different surfactants, cholesterol, and drug amounts, and were characterized for entrapment efficiency, particle size, zeta potential, and stability. Skin permeation studies were performed using hairless mouse skin, and the results showed that the niosomal formulations had a higher retention of minoxidil inside the vesicles and enhanced the percentage of dose accumulated in the skin compared to commercial and control formulations. The study suggests that niosomal formulations could be a promising approach for the topical delivery of minoxidil in hair loss treatment.
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