TLDR Niosomes improve minoxidil skin delivery for hair loss treatment.
This study explores the use of niosomes, a type of vesicular carrier, to improve the skin delivery of minoxidil, a drug used to treat hair loss. The niosomes were prepared using different surfactants, cholesterol, and drug amounts, and were characterized for entrapment efficiency, particle size, zeta potential, and stability. Skin permeation studies were performed using hairless mouse skin, and the results showed that the niosomal formulations had a higher retention of minoxidil inside the vesicles and enhanced the percentage of dose accumulated in the skin compared to commercial and control formulations. The study suggests that niosomal formulations could be a promising approach for the topical delivery of minoxidil in hair loss treatment.
85 citations,
January 2007 in “Journal of Drug Targeting” Liposomes better deliver minoxidil for hair loss treatment than niosomes.
18 citations,
October 2005 in “International Journal of Pharmaceutics” Adding a small amount of TPGS to minoxidil can help hair growth, but too much TPGS reduces this effect and increases minoxidil in the blood.
38 citations,
June 2005 in “Contact Dermatitis” Patient had scalp allergy from minoxidil; test helped identify cause and suggest alternative treatments.
205 citations,
January 2005 in “Skin pharmacology and physiology” Liposomes and niosomes can help drugs penetrate the skin better.
181 citations,
July 2004 in “Journal of controlled release” Smaller nanoparticles improve minoxidil absorption through hair follicles.
149 citations,
April 2004 in “Journal of Dermatological Science” Minoxidil boosts hair growth by increasing cell production and survival.
370 citations,
September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
33 citations,
June 1995 in “Journal of Pharmaceutical Sciences” More ethanol increases minoxidil delivery, but too much lowers efficiency.
48 citations,
December 2013 in “Drug Delivery and Translational Research” Niosomes improve minoxidil skin penetration for hair loss treatment.
85 citations,
January 2007 in “Journal of Drug Targeting” Liposomes better deliver minoxidil for hair loss treatment than niosomes.
