Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

    March 2004 in “ Journal of Dermatological Science ”
    Ji Won Han, Oh Joon Kwon, Jin Wook Chung … Se Kyu Kim
    Studysummary This study found that minoxidil stimulates hair follicle growth by promoting dermal papilla cell survival and activating ERK and Akt pathways, which leads to increased proliferation and reduced cell death.
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    Research cited in this study 16

    1. Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action Dermatology · 2009
    2. Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes Skin Pharmacology and Physiology · 2009
    3. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001
    4. Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice Journal of Dermatological Science · 1998
    5. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    6. In the Absence of Streptomycin, Minoxidil Potentiates the Mitogenic Effects of Fetal Calf Serum, Insulin-Like Growth Factor 1, and Platelet-Derived Growth Factor on NIH 3T3 Fibroblasts in a K+ Channel-Dependent Fashion Journal of Investigative Dermatology · 1996
    7. Effect of Minoxidil Sulfate and Pinacidil on Single Potassium Channel Current in Cultured Human Outer Root Sheath Cells and Dermal Papilla Cells Journal of Dermatological Science · 1994
    8. Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle Journal of Investigative Dermatology · 1994
    9. Potassium Channel Openers Stimulate DNA Synthesis in Mouse Epidermal Keratinocyte and Whole Hair Follicle Cultures Skin Pharmacology and Physiology · 1993
    10. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    11. Human Hair Growth In Vitro Journal of Cell Science · 1990
    12. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990
    13. The Therapeutic Use of Topical Minoxidil Dermatologic Clinics · 1990
    14. Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture Journal of Investigative Dermatology · 1989
    15. Reversal of Baldness in Patient Receiving Minoxidil for Hypertension The New England Journal of Medicine · 1980
    16. Minoxidil in Resistant Hypertension The Lancet · 1977

    Related research 2

    1. Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway International Journal of Molecular Sciences · 2020
    2. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004