Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

April 2004 in “ Journal of Dermatological Science ”

Ji Won Han, Oh Joon Kwon, Jin Wook Chung, Kwang-Hyun Cho, Hee Chul Eun, Se Kyu Kim

minoxidil dermal papilla cells DPCs ERK Akt Bcl-2 Bax anagen hair follicles Rogaine hair growth cell survival

TLDR Minoxidil boosts hair growth by increasing cell production and survival.

The study investigated the effect of minoxidil on dermal papilla cells (DPCs) in human hair follicles. The researchers found that minoxidil increased the proliferation of DPCs and promoted cell survival by activating both ERK and Akt and by preventing cell death by increasing the ratio of Bcl-2/Bax. The study suggests that minoxidil stimulates the growth of human hairs by prolonging anagen through these proliferative and anti-apoptotic effects on DPCs. The study provides insight into the mechanism of topical minoxidil action in stimulating hair growth.

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Research cited in this study

10 / 10 results

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

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Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

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Insulin or IGF-I is needed for hair growth in newborn mice, while minoxidil helps adult mouse hair grow, suggesting a way to study human hair loss.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations, March 1998 in “British Journal of Dermatology”

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research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes

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Minoxidil affects cell growth in two ways: low doses increase growth, while high doses slow it down and can be toxic.

research The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats

53 citations, May 1990 in “Journal of Dermatology”

Minoxidil speeds up hair growth in rats without prolonging growth phase.

research The Therapeutic Use of Topical Minoxidil

33 citations, April 1990 in “Dermatologic Clinics”

Minoxidil effectively treats hair loss, with better results in women.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

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research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

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research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

95 citations, December 1980 in “The New England Journal of Medicine”

Minoxidil helped bald patient regrow hair.

research Minoxidil in Resistant Hypertension

102 citations, September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

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Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

research Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

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research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations, April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

Research cited in this study

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes

research The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats

research The Therapeutic Use of Topical Minoxidil

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension

research Minoxidil in Resistant Hypertension

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research Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle