Minoxidil in Resistant Hypertension

September 1977 in “ The Lancet ”

H. J. Dargie, Colin T. Dollery, Jean-Pierre Daniel

TLDR Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

The study found that minoxidil in combination with propranolol and diuretics can effectively reduce blood pressure in patients with severe hypertension resistant to standard therapy. However, fluid retention was a problem in the minoxidil group. Patients reported feeling better on minoxidil and experienced hypertrichosis (hair growth) as a side effect. The study concludes that minoxidil has a place in the management of severe hypertension refractory to other treatment regimens.

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Research cited in this study

2 / 2 results

$Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension$

research Minoxidil: An Alternative to Nephrectomy for Refractory Hypertension

180 citations, July 1973 in “The New England Journal of Medicine”

Minoxidil effectively lowers blood pressure with few side effects.

research Minoxidil in Severe Hypertension with Renal Failure

100 citations, March 1973 in “American Journal of Cardiology”

Minoxidil effectively lowers blood pressure without major side effects.

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Related Research

2 / 2 results

research Minoxidil in Resistant Hypertension

102 citations, September 1977 in “The Lancet”

Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.

Control Plasma Renin Activity and Changes in Sympathetic Tone as Determinants of Minoxidil-Induced Increase in Plasma Renin Activity

research Control Plasma Renin Activity and Changes in Sympathetic Tone as Determinants of Minoxidil-Induced Increase in Plasma Renin Activity

57 citations, February 1975 in “Journal of Clinical Investigation”

Minoxidil boosts plasma renin activity, influenced by control plasma renin activity and changes in sympathetic tone.