Search

for
Search:

GlossaryB-cell lymphoma 2 (Bcl-2)

protein that inhibits cell death, often overexpressed in cancers

B-cell lymphoma 2 (Bcl-2) is a protein that helps regulate cell death (apoptosis) by inhibiting the process, allowing cells to survive longer than they should. This protein is often overexpressed in certain types of cancer, such as lymphomas, making it a target for cancer therapies aimed at restoring the normal process of cell death.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 1000+ results

research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations , May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations , April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

research A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

17 citations , January 2019 in “Journal of cancer”

The formula YH0618 can reduce the harmful side effects of the chemotherapy drug Doxorubicin and protect healthy cells.

research Effects of Diphencyprone on Expression of Bcl-2 Protein in Patients with Alopecia Areata

13 citations , January 2010 in “Immunopharmacology and immunotoxicology”

Diphencyprone increases Bcl-2 protein in patients with hair regrowth from alopecia areata.

research The Anti-Apoptotic Bcl-2 Protein Regulates Hair Follicle Stem Cell Function

10 citations , August 2021 in “EMBO Reports”

The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.

View more "bcl-2" in research →

Community Join

1 / 1 results

community The end of balding: We may have just found the secret to hair regrowth

in Technology 676 upvotes 6 months ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.