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Glossary Particle Size

dimensions of individual particles in a material

Particle size refers to the dimensions of individual particles in a material, typically measured in micrometers (µm) or nanometers (nm). It is a critical parameter in various fields, including pharmaceuticals, cosmetics, and materials science, as it can influence the behavior, stability, and performance of a product. For example, in the context of hair care products, the particle size of active ingredients can affect how well they penetrate the scalp and hair follicles, potentially impacting the treatment of conditions like alopecia.

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Research

5 / 1000+ results

research Skin permeation of curcumin nanocrystals: Effect of particle size, delivery vehicles, and permeation enhancer

15 citations , February 2023 in “Colloids and surfaces. B, Biointerfaces”

In this study using a porcine skin model, the researchers reported that smaller curcumin nanocrystals in xanthan gum gel showed higher passive skin penetration, while larger particles achieved deeper follicular accumulation.

research Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery

10 citations , February 2022 in “Pharmaceuticals”

This study found that smaller curcumin nanocrystals (60 nm) enhanced transdermal and transfollicular penetration more effectively than larger sizes, influenced by particle size.

research Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy

21 citations , December 2016 in “European journal of pharmaceutics and biopharmaceutics”

This study found that nano-sized lipid particles improved the skin accumulation and retention of dexamethasone compared to a base cream, suggesting potential benefits for inflammatory skin disease treatment.

research The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

128 citations , March 2016 in “Advanced Pharmaceutical Bulletin”

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

research The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study.

71 citations , March 2016 in “PubMed”

This study found that sub-100 nm solid lipid nanoparticles showed the most effective skin penetration and depth, primarily via hair follicles, in rat skin evaluations.

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community Topical Dutasteride usage plan + build up prevention

7 upvotes 10 months ago

The conversation discusses using a 0.03% topical Dutasteride solution for hair loss, as it may be more effective than Finasteride with fewer systemic side effects. OP plans to apply it daily for 100 days, then reduce frequency, due to past negative cognitive effects from oral treatments.

community What happened to topical dutasteride??

in Finasteride/Dutasteride 28 upvotes 1 year ago

Topical dutasteride is considered for hair loss, but concerns about systemic absorption and side effects like reduced libido are common. Users have mixed results, with some preferring oral finasteride or dutasteride despite side effects, while others find topical treatments beneficial but challenging.

community Suggestions on Making DIY Topical Finastride at HOME.

2 upvotes 4 months ago

The conversation discusses making DIY topical finasteride using a hair tonic with various ingredients and suggests alternatives like Jatamansi powder, Sandalore, and products like Bare Anatomy Expert Advanced Hair Growth Serum and RevivHair Max Hair Stimulating Serum. It also mentions using topical dutasteride and minoxidil for hair growth.

community Evaluate your progress with an objective tool

in Progress Pictures 40 upvotes 2 years ago

The post discusses using ImageJ software to objectively track hair regrowth progress. The user is treating Androgen alopecia with dutasteride and minoxidil.

community My progress with various products and without oral fin or oral dut on 17 months

in Progress Pictures 62 upvotes 1 year ago

The user shared their hair loss treatment progress using topical products like exosomes, fluridil, Kx826, and topical dutasteride, avoiding oral finasteride and dutasteride due to side effects. They found exosomes from Creative Biolabs most effective and also used topical probiotics, noting improvements without significant side effects.

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