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Glossary Cholesterol

waxy substance in cells, crucial for hormones and digestion

Cholesterol is a waxy, fat-like substance found in every cell of the body, essential for producing hormones, vitamin D, and substances that help digest foods. While the body needs some cholesterol to function properly, high levels of it in the blood can increase the risk of heart disease by contributing to the formation of plaque in arteries.

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Research

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research Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis

87 citations , March 2014 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

This paper discusses X-linked ichthyosis and its genetic causes, focusing on biochemical pathways and their role in epidermal differentiation and barrier function, but it presents no new clinical findings.

research Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

46 citations , January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Insig deficiency in the skin of mice causes cholesterol precursors to accumulate, leading to defective hair development and skin abnormalities, which were alleviated by simvastatin treatment.

research The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum

27 citations , July 1982 in “British Journal of Dermatology”

The antiandrogen 11α-hydroxyprogesterone effectively reduces skin oil and cholesterol when applied to the skin.

research Cholesterol homeostasis: Links to hair follicle biology and hair disorders

25 citations , July 2019 in “Experimental Dermatology”

This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

In this study, researchers found that impaired cholesterol biosynthesis in hair follicles may trigger an inflammatory immune response linked to primary cicatricial alopecia, providing new insights into the disorder's pathogenesis.

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Community Join

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community High cholesterol causes hair loss?

16 upvotes 2 years ago

High cholesterol may lead to hair loss by causing cicatricial alopecia, an inflammatory disorder. Treatments discussed include cholesterol medication and statins.

community Dutasteride and elevated (LDL) cholesterol

1 upvotes 1 year ago

The user switched from finasteride to dutasteride for hair loss and noticed elevated cholesterol levels, questioning if dutasteride caused this change. They also take Vitamin D, biotin, magnesium, ginkgo biloba, omega-3, and NAC, and are concerned about the impact of these supplements and their health on cholesterol levels.

community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

131 upvotes 1 year ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

community Anyone experienced weight gain on dutasteride?

5 upvotes 4 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community A warning to those using or thinking about using Dutasteride – Follow-up

18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

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Learn

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learn cholecalciferol

learn Choline

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