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    Glossary Squalene

    natural compound in sebum, precursor to cholesterol

    Squalene is a natural organic compound that is a precursor to cholesterol and other steroids. It is found in high concentrations in shark liver oil, but also occurs in olive oil, wheat germ oil, and the human sebum. Squalene is valued for its moisturizing properties and is often used in skincare products to help maintain skin hydration and barrier function.

    Related Terms

    Learn 1

    1. squalane

    Research 10 of 357

    1. Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata Pharmaceutical Research · 2012 · 59 citations
    2. Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases Pharmaceutics · 2020 · 15 citations
    3. Quantification of Squalene and Lactic Acid in Hair Bulbs with Damaged Sheaths: Are They Metabolic Wastes in Alopecia? Biomedicines · 2023
    4. Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli Mediators of Inflammation · 2010 · 105 citations
    5. TREM2 macrophages induced by human lipids drive inflammation in acne lesions Science Immunology · 2022 · 62 citations
    6. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013 · 62 citations
    7. Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems Journal of Drug Delivery Science and Technology · 2015 · 47 citations
    8. Characterization of the lipid composition at the proximal root regions of human hair International Journal of Cosmetic Science · 2005 · 41 citations
    9. Prevention of lipid loss from hair by surface and internal modification Scientific reports · 2019 · 17 citations
    10. On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections International Journal of Cosmetic Science · 2010 · 17 citations
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    Community 2

    1. Switching RU vehicle due to scalp irritation – anyone tried low-EtOH + squalane / emu oil? Reddit · 6 Dec 2025
    2. Min and retinol? Anyone tried it? Reddit · 6 Oct 2023