Effect of Physical Stimuli on Hair Follicle Deposition of Clobetasol-Loaded Lipid Nanocarriers

January 2020 in “ Scientific Reports ”

Tamara Ângelo, Nesma El‐Sayed, Marijas Jurisic, Aljoscha Koenneke, Guilherme M. Gelfuso, Marcílio Cunha‐Filho, Stephânia Fleury Taveira, Robert Lemor, Marc Schneider, Taís Gratieri

clobetasol nanostructured lipid carriers NLC hair follicles manual massage ultrasound treatment mechanical vibration drug delivery skin layers clobetasol cream lipid nanocarriers hair follicle targeting massage ultrasound vibration drug absorption skin penetration

TLDR NLCs with manual massage greatly improve clobetasol delivery to hair follicles.

The study investigated the effectiveness of clobetasol-loaded nanostructured lipid carriers (NLC) for targeting hair follicles compared to a commercial cream, and the impact of various physical stimuli on drug delivery. The NLCs significantly increased clobetasol uptake in hair follicles by about 40 times compared to the commercial cream. Manual massage was the most effective physical stimulus, doubling the follicular retention of clobetasol compared to passive application. Ultrasound treatment, especially with mechanical vibration, also enhanced drug retention in deeper skin layers. The study concluded that NLCs were promising for delivering clobetasol to hair follicles, with manual massage being a simple yet effective method to enhance drug delivery. The study involved in vitro experiments with a sample size of 6.

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