Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

    December 2015 in “ Journal of Controlled Release ”
    Christiane Mathes, Ana Melero, Peter Conrad, Thomas Vogt, Lucas Almeida Rigo, Dominik Selzer, Willian Andrade Prado, Chiara Rossi, Teresa Garrigues, Steffi Hansen, Sı́lvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Ruy Carlos Ruver Beck, Claus‐Michael Lehr, Ulrich F. Schaefer
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    TLDR Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.
    The study investigated the use of polymeric nanocarriers to optimize the delivery of clobetasol propionate (CP) for treating inflammatory scalp diseases while minimizing adverse effects. Three types of nanocarriers—nanospheres, nanocapsules, and lipid-core nanocapsules—were tested, with nanocapsules showing the highest follicular uptake, especially when applied with massage, and reduced transdermal permeability compared to the free drug. This suggested that nanocapsules could effectively target hair follicles and decrease interfollicular drug penetration, offering a promising strategy for improving drug delivery and reducing side effects in topical glucocorticoid treatments. The study provided a foundation for future clinical trials involving CP nanocarriers, potentially enhancing treatment efficacy and safety for conditions like alopecia areata and scalp psoriasis.
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