Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

    December 2015 in “ Journal of Controlled Release ”
    Christiane Mathes, Ana Melero, Peter Conrad … Ulrich F. Schaefer
    Studysummary This study found that nanocapsules formulated as a dispersion and applied with massage may enhance follicular uptake of clobetasol propionate while minimizing its skin penetration, offering a potential improvement over conventional treatments for scalp diseases.
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    Research cited in this study 12

    1. Comparison of Systemic Mycophenolate Mofetil with Topical Clobetasol in Lichen Planopilaris: A Parallel-Group, Assessor- and Analyst-Blinded, Randomized Controlled Trial American journal of clinical dermatology · 2015
    2. Quantification of Nanoparticle Uptake Into Hair Follicles in Pig Ear and Human Forearm Journal of Controlled Release · 2014
    3. Clobetasol Propionate, 0.05%, vs Hydrocortisone, 1%, for Alopecia Areata in Children JAMA dermatology · 2013
    4. An Atlas of Hair Pathology with Clinical Correlations CRC Press eBooks · 2012
    5. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    6. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    7. Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions European journal of pharmaceutics and biopharmaceutics · 2009
    8. Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    9. Efficacy And Safety Of A New Clobetasol Propionate 0.05% Foam In Alopecia Areata: A Randomized, Double-Blind Placebo-Controlled Trial Journal of the European Academy of Dermatology and Venereology · 2006
    10. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    11. Clobetasol Propionate 0.05% Under Occlusion in the Treatment of Alopecia Totalis/Universalis Journal of the American Academy of Dermatology · 2003
    12. Distribution of Human Hair in Follicular Units Dermatologic Surgery · 1999