Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions
February 2009
in “
European journal of pharmaceutics and biopharmaceutics
”
Studysummary This study found that porcine ear skin is more suitable than excised human skin for investigating the efficacy of barrier emulsions in preventing pollen allergen penetration due to its lack of tissue contraction.
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The study compared the efficacy of barrier emulsions in preventing pollen allergen penetration into hair follicles using two in vitro models: excised human skin and porcine ear skin. It was found that porcine ear skin was a more suitable model due to its lack of contraction post-removal, unlike human skin which contracts and may not accurately represent follicular penetration. The results indicated that porcine ear skin provided a better platform for analyzing follicular penetration, suggesting that excised human skin might not be reliable for such studies.
