Establishment of an Evaluation Method to Detect Drug Distribution in Hair Follicles

February 2018 in “ International Journal of Pharmaceutics ”

Akinari Abe, Miyuki Saito, Wesam R. Kadhum, Hiroaki Todo, Kenji Sugibayashi

cyanoacrylate biopsy hair follicles caffeine 4-butylresorcinol topical application hydrophilic drug lipophilic drug skin permeation CB method CAF BR

Studysummary This study found that the cyanoacrylate biopsy method could effectively evaluate drug distribution in hair follicles, suggesting its potential utility for assessing topically applied chemicals targeting hair follicles.

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research Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals

39 citations , November 2016 in “Pharmaceutics”

This study found that the contribution of the hair follicle pathway to skin permeation of chemicals can be predicted using lipophilicity, with hydrophilic chemicals showing greater permeation reduction from hair follicle plugging than lipophilic ones.

Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

research Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

94 citations , May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

This study found that hair follicles contribute significantly to caffeine absorption shortly after topical application, with a faster absorption rate compared to the stratum corneum.

research Methods for Quantifying Intrafollicular Drug Delivery: A Critical Appraisal

34 citations , July 2010 in “Expert Opinion on Drug Delivery”

This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.

research Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam

74 citations , June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that hair follicles are a significant and efficient pathway for the absorption of topical minoxidil foam in humans, with faster blood detection when follicles are open.

research Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data

82 citations , May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

The study reported that combining the Follicular Closing Technique with the Franz diffusion cell is a valuable method for investigating follicular caffeine penetration in vitro, though kinetics differ from in vivo results.

research Follicular Transport Route: Research Progress and Future Perspectives

211 citations , February 2009 in “European journal of pharmaceutics and biopharmaceutics”

This review summarizes recent advancements in follicular targeting for drug delivery via hair follicles and calls for pilot studies in humans to explore potential clinical applications.

research Factors Influencing Hydrocortisone Permeation Into Human Hair Follicles: Use of the Skin Sandwich System

16 citations , March 2008 in “International journal of pharmaceutics”

This study found that formulation factors like pH, viscosity, and chemical enhancers can significantly influence intrafollicular hydrocortisone permeation in vitro, with higher pH and enhancers reducing follicular contribution.

research Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil

102 citations , February 2008 in “The FASEB Journal”

This study found that human hair follicles express ATP-sensitive potassium channels, suggesting that minoxidil acts on these channels and that drugs targeting them may treat hair disorders.

research In Vitro Permeation of Drugs Into Porcine Hair Follicles: Is It Quantitatively Equivalent to Permeation Into Human Hair Follicles?

19 citations , January 2008 in “Journal of Pharmacy and Pharmacology”

This study found that porcine skin serves as a reliable model for studying drug absorption into human hair follicles, showing a strong correlation in follicular drug absorption between porcine and human skin.

research The Role of Hair Follicles in the Percutaneous Absorption of Caffeine

182 citations , December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

This study demonstrated that hair follicles significantly expedite the absorption of caffeine through the skin compared to interfollicular pathways.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study introduces a novel non-invasive method called "differential stripping" to quantify the penetration of topically applied substances into hair follicles.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations , March 2004 in “Journal of Dermatological Science”

This study found that minoxidil stimulates hair follicle growth by promoting dermal papilla cell survival and activating ERK and Akt pathways, which leads to increased proliferation and reduced cell death.

research Variations of Hair Follicle Size and Distribution in Different Body Sites

405 citations , January 2004 in “Journal of Investigative Dermatology”

This study found that hair follicle characteristics vary significantly across different body sites, with the forehead and calf showing the highest potential follicular reservoirs, challenging previous assumptions about skin appendage distribution.

research Safety of Topical Minoxidil Solution: A One-Year, Prospective, Observational Study

26 citations , July 2003 in “Journal of Cutaneous Medicine and Surgery”

This study found that topical minoxidil solution is a safe treatment for androgenetic alopecia, with no increase in cardiovascular events or adverse pregnancy outcomes observed.

research Permeant Lipophilicity and Vehicle Composition Influence Accumulation of Dyes in Hair Follicles of Human Skin

44 citations , April 2003 in “European journal of pharmaceutical sciences”

This study found that targeting the hair follicle can be increased by using lipophilic drugs combined with surfactant solutions and propylene glycol.

Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

research Transfollicular Drug Delivery: Penetration of Drugs Through Human Scalp Skin and Comparison of Penetration Between Scalp and Abdominal Skins In Vitro

82 citations , January 2002 in “Journal of drug targeting”

This study found that drug delivery through human scalp skin may be more effective for lipophilic and hydrophilic drugs compared to abdominal skin, highlighting the potential of intrafollicular delivery methods.

research Minoxidil and Male-Pattern Alopecia: A Potential Role for a Local Regulator of Sebum Secretion with Vasoconstrictive Effects?

5 citations , November 1999 in “Medical Hypotheses”

Minoxidil, a common hair loss treatment, might work by counteracting a hormone that reduces hair growth and promotes hair loss.

research Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles

166 citations , November 1990 in “Journal of Investigative Dermatology”

Minoxidil sulfate stimulates hair growth.