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Glossary Hydrophilic Drugs

dissolve easily in water for quick absorption

Hydrophilic drugs, also known as water-soluble drugs, are medications that dissolve easily in water. This property allows them to be readily absorbed into the bloodstream when taken orally or administered intravenously. Because they mix well with bodily fluids, hydrophilic drugs often have a quicker onset of action and are less likely to accumulate in fatty tissues, making them suitable for treating conditions that require rapid therapeutic effects.

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Research

5 / 1000+ results

research Emulgel: A Novel Approach For Hydrophobic Drugs

13 citations , April 2019 in “American Journal of PharmTech Research”

In this study, researchers highlighted that emulgels, a combination of emulsions and gels, offer a novel topical delivery method for hydrophobic drugs, possessing attributes such as easy spreadability and bio-friendliness, making them suitable for conditions like acne, fungal infections, and psoriasis.

Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles

research Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles

December 2023 in “Biological & pharmaceutical bulletin”

This study found that combining lecithin reverse wormlike micelles with isopropyl myristate enhanced the skin permeability of a model hydrophilic drug, facilitated by interactions with sebum in hair follicles.

research Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems

47 citations , September 2015 in “Journal of Drug Delivery Science and Technology”

This article reviews various strategies, primarily developed by the Turin University Pharmaceutical Technology group, for increasing entrapment efficiency of hydrophilic molecules in nanoparticulate systems and reports no clinical results.

research Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

260 citations , January 2019 in “Pharmaceutics”

This study highlights that niosomes, or non-ionic surfactant based vesicles, offer an advantageous drug delivery system due to their stability, cost-effectiveness, and ability to enhance drug bioavailability and targeting efficiency for various therapeutic agents.

research Liposomal systems as drug delivery vehicles for dermal and transdermal applications

151 citations , July 2011 in “Archives of Dermatological Research”

This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.

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Community Join

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community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

2 upvotes 2 years ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

23 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

192 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Alcohol-free minoxidil available in Europe

5 upvotes 9 months ago

Alcohol-free minoxidil options in Europe, particularly from a German pharmacy, are recommended for those with seborrheic dermatitis. Users suggest alternatives like Alopexy and Doppelherz foam, and emphasize avoiding propylene glycol and alcohol to reduce irritation.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

124 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

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learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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