Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles

    Yoshiyuki Miyasaka, Kaname Hashizaki, Kazuo Shibasaki … Hiroyuki Taguchi
    Studysummary This study found that combining lecithin reverse wormlike micelles with isopropyl myristate enhanced the skin permeability of a model hydrophilic drug, facilitated by interactions with sebum in hair follicles.
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    Research cited in this study 3

    1. Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals Pharmaceutics · 2016
    2. Comparison of Rheological Properties, Follicular Penetration, Drug Release, and Permeation Behavior of a Novel Topical Drug Delivery System and a Conventional Cream European journal of pharmaceutics and biopharmaceutics · 2014
    3. Lecithin Organogels as a Potential Phospholipid-Structured System for Topical Drug Delivery: A Review Aaps Pharmscitech · 2005