Polymeric Nanoparticles-Embedded Organogel for Roxithromycin Delivery to Hair Follicles

July 2014 in “ European Journal of Pharmaceutics and Biopharmaceutics ”

Eliza Główka, Hanna Wosicka-Frąckowiak, Kinga Hyla, Justyna Stefanowska, Katarzyna Jastrzębska, Łukasz Klapiszewski, Teofil Jesionowski, Krzysztof Cal

polymeric nanoparticles organogel roxithromycin pluronic lecithin organogel poly(epsilon-caprolactone) PCL zeta potential encapsulation efficiency biphasic release ex vivo human skin penetration pilosebaceous unit androgenetic alopecia anti-apoptotic properties PLO ROX hair follicles hair shaft

Studysummary This study concluded that polymeric nanoparticles effectively targeted hair follicles for drug delivery, but the organogel formulation did not enhance their penetration into the hair shaft.

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