Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

    May 2015 in “ Nanomedicine: Nanotechnology, Biology and Medicine ”
    Ibrahim A. Aljuffali, Tai-Long Pan, Calvin T. Sung, Shu-Hao Chang, Jia-You Fang
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    TLDR Scientists created tiny particles loaded with a hair growth drug, minoxidil, that specifically target hair follicles and skin cells to potentially improve hair growth.
    In 2015, researchers developed lipid nanocarriers, or squarticles, loaded with minoxidil and conjugated with anti-platelet-derived growth factor (PDGF)-receptor ß antibody for targeted alopecia treatment. These nanoparticles, with a mean diameter of 195 nm and a zeta potential of -46 mV, were designed to target hair follicles and dermal papilla cells (DPCs). The encapsulation of minoxidil in these nanoparticles increased its deposition in skin and enhanced follicular uptake by 3-fold in a mouse model. The study also found that the encapsulated minoxidil stimulated DPC proliferation and vascular endothelial growth factor (VEGF) expression, suggesting potential for improved hair growth. However, further studies were needed to explore the delivery pathways and hair growth activity of these nanocarriers in animals.
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