Targeting to the Hair Follicles: Current Status and Potential

The pilosebaceous unit, comprising hair follicles and sebaceous glands, was identified as a key target for localized and systemic drug delivery due to its complex growth cycle and specific drug targeting sites. The article reviewed methods like differential stripping to assess follicular penetration and discussed factors affecting this process, such as follicle activity, size, and distribution. Improved penetration was noted with particle-based formulations, though contradictions highlighted the need for further research.