TLDR Killing specific cells in hair follicles can lead to hair growth problems in mice.
The study conducted on newborn BALB/c mice demonstrated that label-retaining cells (LRCs) in the hair follicle bulge region are essential for follicular renewal. By selectively eliminating these cells using a photo-induced cell killing method, researchers observed a defect in hair follicle regeneration in 8 out of 41 cases during the anagen phase. The results indicated that LRCs are important for the supply of germinative cells necessary for hair growth, supporting the idea that LRCs are follicular stem cells. The study's findings also suggest that the late telogen phase is a sensitive period for LRCs in terms of irradiation damage.
73 citations,
January 2002 in “Journal of Investigative Dermatology” Epidermal stem cells don't use gap junctions to communicate.
949 citations,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
130 citations,
January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
68 citations,
December 1991 in “Annals of the New York Academy of Sciences” Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
521 citations,
January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
21 citations,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
8 citations,
September 2002 in “Genes to Cells” Killing specific cells in hair follicles can lead to hair growth problems in mice.
