Inductive Properties of Hair Follicle Cells

    Amanda J. Reynolds, Colin A.B. Jahoda
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    TLDR Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
    The 2006 study "Inductive Properties of Hair Follicle Cells" explored the hair growth inducing properties of dermal papilla cells found at the base of hair follicles. Experiments showed that these cells, when implanted into rat ears, induced the growth of large fibers. However, dermal sheath cells, despite their proximity to papilla cells, did not have the same inductive capabilities. The study also found that cells from the dental papilla of mature rat incisors could induce fiber formation when implanted into ear wounds. The research provided evidence supporting hair follicle neogenesis and the developmental plasticity of epidermal cells. It also suggested common regulatory mechanisms in dermal-epidermal interactions and inductive signals of papilla cells across different species. The document also discussed the movement of outer root sheath (ORS) cells in hair follicles, suggesting different mechanisms in vibrissa and pelage hair follicles due to varying degrees of follicle shortening at telogen.
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